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Stem Cell Treatments For Cerebral Palsy Factsheet For - UCLA ...

STEM CELLS AND CEREBRAL PALSY Cerebral palsy (CP) is an umbrella term which includes several forms and levels of nonprogressive brain-related injury, which cause limitations in muscle control, movement and mobility (known as neuromotor impairment) and other symptoms that lead to physical disability. CP is caused by many factors, and can include infection before birth, premature birth and lack of oxygen around the time of birth. It is thought that the major common feature in CP is a lack of blood and oxygen to the brain during fetal development and/or delivery, known as a hypoxic-ischemic insult. The cells most vulnerable to this hypoxic-ischemic insult are oligodendrocytes, the support cells that wrap nerve cells (or neurons) with a protective white fat called myelin, hence the term white matter of the brain. Because of this myelin, neurons can send electrical signals efficiently throughout the body. Once oligodendrocytes die, the neurons are no longer protected and they eventually die. If myelin could be replaced before neurons die, neurons could be spared and motor impairments could be lessened. For this reason, scientists are investigating whether lost oligodendrocytes can be replaced with stem cells. Stem cells are unspecialized cells which can become specialized cells such as brain cells, heart cells or muscle cells. The process of developing into a specialized cell is known as differentiation. Stem cells can also multiply over and over again, a process known as proliferation. During the process of proliferation the stem cell either remains unspecialized or, under the right condition, can become a specialized cell such as a brain cell. Replacing neurons themselves would be like trying to rewire a giant switchboard with tens of thousands of ports but no labels, where improper connections could lead to pain. It is for this reason that the aim of many cell transplantation strategies now being tested is to replace lost oligodendrocytes rather than to make and successfully connect new neurons. Recent decades have seen advances in our knowledge of how to study and use stem cells. It is expected we will develop ways to transplant stem cells into damaged tissues to treat and cure injury and diseases like CP. From Mice to Humans...

Stem cell therapy in a caprine model of osteoarthritis - Wiley Online ...

Stem Cell Therapy in a Caprine Model of Osteoarthritis J. Mary Murphy,1 David J. Fink,1 Ernst B. Hunziker,2 and Frank P. Barry1 Objective. To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). Methods. Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA was induced unilaterally in the knee joint of donor animals by complete excision of the medial meniscus and resection of the anterior cruciate ligament. After 6 weeks, a single dose of 10 million autologous cells suspended in a dilute solution of sodium hyaluronan was delivered to the injured knee by direct intraarticular injection. Control animals received sodium hyaluronan alone. Results. In cell-treated joints, there was evidence of marked regeneration of the medial meniscus, and implanted cells were detected in the newly formed tissue. Degeneration of the articular cartilage, osteophytic remodeling, and subchondral sclerosis were reduced in cell-treated joints compared with joints treated with vehicle alone without cells. There was no evidence of repair of the ligament in any of the joints. Conclusion. Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA.

2013 Brochure - Carolina Computing Initiative

Why Should I Purchase a CCI Laptop? You’ll want to purchase one of the official CCI Laptops because the laptop packages available to you as an entering UNC-Chapel Hill student are the best value anywhere. Our comprehensive program of hardware, software, and support ensures an unparalleled student computing experience. Only with the purchase of a CCI Laptop will you be eligible for all the programs and services below: • A 4-year Comprehensive Protection Plan including: 4 Years of Manufacturer’s Warranty Coverage 4 Years of Accidental Damage Coverage 4 Years of Laptop Insurance Coverage • Computer Support 24 x 7 • An Award-winning On-campus Repair Center with a pool of loaner laptops • An Extensive Software Package • Security Solutions for keeping your computer and data secured When should I place my order? 8 out of 10 Carolina undergraduates choose a CCI Laptop package to fulfill the laptop requirement. CCI Laptop packages can be ordered through the CCI Website starting in early April. Submit your order by May 15 and your laptop will be waiting for you at your New Student Orientation session this summer. Students admitted after May 15 should order as soon as possible and at least 2 weeks before your New Student Orientation. How do I order my CCI Laptop? [1] Decide which CCI Laptop model you want to purchase [2] Choose Your Printer [3] Choose Your Accessories They will get more than award-winning laptops. They will get support, service, [4] Place Your Order through the CCI website or Call 919-962-8534 Monday-Friday 10am-5pm and software ensuring them an unparalleled student computing experience. How do I pay for my CCI Laptop? [1] Credit Card (Visa, Mastercard or American Express) [2] Laptop grant from the University What if I don’t buy a CCI Laptop? Please note that, while students are not required to purchase a CCI Laptop, students are required to have a laptop that meets the minimum requirements specified. Software and operating system support for non-CCI laptops is on a best-effort basis. Hardware support for non-CCI laptops is the responsibility of the owner. Loaner laptops are only available to students who purchase a CCI Laptop through UNC Student Stores. If you have any additional questions please visit our FAQ...

MLTI Participation Packet 2013 MLTI Apple Alternate ... - Maine.gov

MLTI Apple Alternate Solution THIS PACKET CONTAINS: MLTI Apple Program Description Student and Staff Eligibility Guidelines Participation and Funding Information MLTI Participation Form 2013 M a i n e L e a r n i n g Te c h n o l o g y I n i t i a t i v e • M a i n e D e p a r t m e n t o f E d u c a t i o n • 2 3 S t a t e H o u s e S t a t i o n • A u g u s t a M a i n e • 0 4 3 3 3 - 0 0 2 3 • Vo i c e ( 2 0 7 ) 6 2 4 - 6 7 4 6 • FA X 8 7 7 - 4 9 4 - M LT I ( 6 5 8 4 ) 1 M A I N E L E A R N I N G T E C H N O L O G Y I N I T I AT I V E 2013-2017 Deployment IV MLTI Apple Program Description Goals The MLTI goals remain: • Equity • Integration with Maine’s Learning Results • Sustainability / Avoiding Obsolescence • Teacher Preparation and Professional Development • Economic Development At a school and classroom level, these goals can be translated into a few more tangible actionable goals: 1) changing teacher practices in ways that leverage technology to facilitate a student-centered learning environment, and 2) active participation in on-going professional development efforts. Professional Development Apple Professional Development (APD) brings educational experience and curriculum knowledge to every workshop delivered. With over 10 years of collaborative work in Maine, the APD team is comprised of trained educators with years of classroom and leadership experience. APD delivers comprehensive professional development programs focused on supporting classroom teachers along with building and district leaders. The comprehensive Professional Development plan outlined in this solution focuses on teaching and learning best practices underpinned by a long-term association with the SAMR Model, learned from the work done with MLTI. An emphasis on hands-on, engaging learning is foundational to the offerings outlined from Apple Professional Development. Whether through the use of online resources from iTunes U, face-to-face engagement in a traditional workshop setting, classroom coaching and mentoring, or as part of the Leadership Cadres, Apple’s comprehensive Professional Development plan is ready to take Maine educators to new levels of capability and effectiveness. M a i n e L e a r n i n g Te c h n o l o g y I n i t i a t i v e • M a i n e D e p a r t m e n t o f E d u c a t i o n • 2 3 S t a t e H o u s e S t a t i o n • A u g u s t a M a i n e • 0 4 3 3 3 - 0 0 2 3 • Vo i c e ( 2 0 7 ) 6 2 4 - 6 7 4 6 • FA X 8 7 7 - 4 9 4 - M LT I ( 6 5 8 4 ) ...

Overestimated global warming over the past 20 years

G lobal mean surface temperature over the past 20 years (1993–2012) rose at a rate of 0.14 ± 0.06 °C per decade (95% confidence interval)1. This rate of warming is significantly slower than that simulated by the climate models participating in Phase 5 of the Coupled Model Intercomparison Project (CMIP5). To illustrate this, we considered trends in global mean surface temperature computed from 117 simulations of the climate by 37 CMIP5 models (see Supplementary Information). These models generally simulate natural variability — including that associated with the El Niño–Southern Oscillation and explosive volcanic eruptions — as well as estimate the combined response of climate to changes in greenhouse gas concentrations, aerosol abundance (of sulphate, black carbon and organic carbon, for example), ozone concentrations (tropospheric and stratospheric), land use (for example, deforestation) and solar variability. By averaging simulated temperatures only at locations where corresponding observations exist, we find an average simulated rise in global mean surface temperature of 0.30 ± 0.02 °C per decade (using 95% confidence intervals on the model average). The observed rate of warming given above is less than half of this simulated rate, and only a few simulations provide warming trends within the range of observational uncertainty (Fig. 1a). The inconsistency between observed and simulated global warming is even more striking for temperature trends computed over the past fifteen years (1998–2012). For this period, the observed trend of 0.05 ± 0.08 °C per decade is more than four times smaller than the average simulated trend of 0.21 ± 0.03 °C per decade (Fig. 1b). It is worth noting that the observed trend over this period — not significantly...

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Acer Aspire 5315 Manual Download - User Manual World

Changes may be made periodically to the information in this publication without obligation to notify any person of such revisions or changes. Such changes will be incorporated in new editions of this manual or supplementary documents and publications. This company makes no representations or warranties, either expressed or implied, with respect to the contents hereof and specifically disclaims the implied warranties of merchantability or fitness for a particular purpose. Record the model number, serial number, purchase date and place of purchase information in the space provided below. The serial number and model number are recorded on the label affixed to your computer. All correspondence concerning your unit should include the serial number, model number and purchase information. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronically, mechanically, by photocopy, recording or otherwise, without the prior written permission of Acer Incorporated. Aspire 5715Z/5315 Series Notebook PC

THE ANNE FORD SCHOLARSHIP - National Center for Learning ...

The National Center for Learning Disabilities is seeking applicants for the 2013-2014 Anne Ford Scholarship. The Anne Ford Scholarship is a $10,000 ($2,500/year over four years) award granted to a graduating high school senior with a documented learning disability who will be enrolled, in the fall of 2014, in a full-time bachelor’s degree program. The ideal Anne Ford Scholar is a student who: • Articulates his/her LD and clearly demonstrates the importance of self-advocacy • Is committed to completing a four-year college degree and has begun to set realistic career goals • Participates in school and community activities • Has demonstrated academic achievements consistent with college and career goals • Plans to contribute to society in ways that increase opportunities for individuals with LD • Excels as a role model and spokesperson for others who struggle with LD • Demonstrates financial need Eligibility & Selection Criteria To be eligible for the 2013-2014 Anne Ford Scholarship, an applicant must: • Have an overall Grade Point Average (GPA) of 3.0 or higher on a 4 point scale (or equivalent) • Demonstrate financial need • Provide most current documentation of an identified learning disability Please Note: ADD/ADHD alone is not considered a learning disability; eligible candidates must also provide documentation of a specific learning disability. • Be a U.S. Citizen Please Note: If you will be attending a two-year community college, vocational or technical training program, or specialized program for students with LD, you are not eligible to apply for the Anne Ford Scholarship. Please visit our website at www.LD.org for more information on the Allegra Ford Scholarship. “I learn differently than everyone else but I do not allow that to limit how much I am able to learn.” - Macy Olivas, 2009 Anne Ford Scholar http://www.ld.org AFScholarship@ncld.org (888) 575-7373 the anne ford scholarship National Center for Learning Disabilities Mentoring & Outreach Opportunities The Anne Ford Scholar must be willing to mentor future Scholars and act as a role model for individuals with learning disabilities through such activities as public speaking, writing for publications, and engaging in other opportunities made possible through NCLD. Selection Process The Anne Ford Scholarship Committee, comprised of members of NCLD’s Board of Directors, Professional Advisory Board, and distinguished friends, will make the final selection of scholars in Spring 2014. Scholarship Requirements Anne Ford Scholars are required to submit annual updates detailing their progress in school and offering insights about their academic and personal growth. The $10,000 scholarship will be paid in four yearly installments of $2,500. Scholars must submit proof of course registration to receive their first installment. To continue receiving payments, scholars must provide proof of course registration for each ensuing semester and documentation of passing grades (transcripts).

Finding The chinese language Interpreter

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Attain Excellence With Student Management Systems

Important Specifications of School Management SoftwareIt's a delighting encounter for the college to roll out from the traditional administration model for the on the net platform. Exciting as it sounds, but a lot of schools actually fuels out by the time the school management software is up and operating.

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