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Cell therapy medical tourism: Time for action - Celltherapysociety.org

Department of Research and Development, Hospira Inc., Lake Forest, Illinois, USA, 2Department of Medical Ethics, University of Pennsylvania, Philadelphia, Pennsylvania, USA, 3Advanced Centre for Biochemical Engineering, University College London, London, UK, 4The Stop ALD Foundation, Houston, Texas, USA, 5Interdisciplinary Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA, 6Department of Regulatory Affairs, Perkin Elmer Inc., Cambridge, Massachusetts, USA, 7Bone Marrow Transplantation Unit, National Cancer Institute, Rio de Janeiro, Brazil, 8Section of Hematology and Bone Marrow Transplantation Unit, University Hospital, Cremona, Italy, 9Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA, 10Department of Cell and Molecular Therapies, Royal Prince Alfred Hospital RPA Hospital and Centenary Institute, Newtown, NSW Australia, 11Research Foundation for , Community Medicine, Tokyo, Japan, and 12Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Key Words: cell therapy, stem cell, medical tourism, medical ethics, informed consent, regulatory affairs

Patient Advisory for Stem Cell Therapy and Medical Tourism

August 2013 Patient Advisory for Stem Cell Therapy and Medical Tourism As stakeholders in cellular therapy, the undersigned professional organizations believe it is necessary to share the following important message with patients and families contemplating cell therapy or experimental stem cell procedures. In this document, best practices are outlined to assist patients and family members in their healthcare decisions. Controlled innovation in the context of patient safety is paramount as potential therapeutic products or procedures are researched, tested, advanced and proven. Our organizations have received questions and concerns from patients and this document presents an opportunity to address them. Introduction Advancement of clinical therapies is best done in the setting of rigorous and formal clinical trials and in a structured regulatory framework. This helps assure that safety considerations, professional peer review, and the management of patient rights and obligations are considered and addressed. Some procedures would be considered standard of care, because scientific studies have shown that they are safe and effective. Not all procedures offered to patients in all regions of the world are tested in this manner and not all geographical regions have regulations for cellular therapies or patient protection. Additionally, it is possible that some practitioners may offer stem cell procedures without following the existing regulations. Patients may be seeking treatment for incurable, potentially untreatable diseases and may be susceptible to false promises or may not have access to all of the information needed to make this important decision. As patients and families contemplate voluntarily ...

Cardiac Stem Cell Therapy and the Promise of Heart Regeneration

Perspective Cardiac Stem Cell Therapy and the Promise of Heart Regeneration Jessica C. Garbern1 and Richard T. Lee2,* 1Department of Medicine, Boston Children’s Hospital, Boston, MA 02115, USA Stem Cell Institute, the Brigham Regenerative Medicine Center and the Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA *Correspondence: rlee@partners.org http://dx.doi.org/10.1016/j.stem.2013.05.008 2Harvard Stem cell therapy for cardiac disease is an exciting but highly controversial research area. Strategies such as cell transplantation and reprogramming have demonstrated both intriguing and sobering results. Yet as clinical trials proceed, our incomplete understanding of stem cell behavior is made evident by numerous unresolved matters, such as the mechanisms of cardiomyocyte turnover or the optimal therapeutic strategies to achieve clinical efficacy. In this Perspective, we consider how cardiac stem cell biology has led us into clinical trials, and we suggest that achieving true cardiac regeneration in patients may ultimately require resolution of critical controversies in experimental cardiac regeneration. Introduction The race is on: throughout the world, basic and clinical investigators want to be the first to identify new approaches to regenerate cardiac tissue and to prove the effects of these therapies in patients with heart disease. Despite substantial progress in treating many types of heart disease, the worldwide heart failure burden will remain enormous through this century. The potential of stem cells and the scope of the heart failure problem have fueled a stampede to be the first to achieve human heart regeneration. Cell transplantation approaches are attractive given their...

Stem Cell Therapy: the ethical issues - Nuffield Council on Bioethics

Stem Cell Therapy: the ethical issues a discussion paper Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3EG Telephone: Fax: Email: Website: 020 7681 9619 020 7637 1712 bioethics@nuffieldfoundation.org http://www.nuffieldfoundation.org/bioethics April 2000 © Nuffield Council on Bioethics 2000 All rights reserved. Apart from fair dealing for the purpose of private study, research, criticism or review, no part of the publication may be produced, stored in a retrieval system or transmitted in any form, or by any means, without prior permission of the copyright owners. Nuffield Council on Bioethics Professor Ian Kennedy (Chairman) Professor Martin Bobrow CBE (Deputy Chairman) Professor Tom Baldwin Professor Sir Kenneth Calman KCB FRSE* Reverend Professor Duncan Forrester DD Professor Brian Heap CBE FRS Mrs Rebecca Howard Lady Hornby Professor John Ledingham Mr Derek Osborn CB Professor Catherine Peckham CBE Professor Martin Raff FRS Mr Nick Ross Professor Herbert Sewell Professor Albert Weale FBA * (co-opted member of Council for the period of his Chairmanship of the Working Party on the ethics of healthcare-related research in developing countries) The terms of reference are as follows: 1 to identify and define ethical questions raised by recent advances in biological and medical research in order to respond to, and to anticipate, public concern; 2 to make arrangements for examining and reporting on such questions with a view to promoting public understanding and discussion; this may lead, where needed, to the formulation of new guidelines by the appropriate regulatory or other body; 3 in the light of the outcome of its work, to publish reports; and to make representations, as the Council may judge appropriate. The Nuffield Council on Bioethics is funded jointly by the Medical Research Council, the Nuffield Foundation and the Wellcome Trust Attendees of the Round Table meeting on Stem Cell Therapy: the ethical issues Professor Martin Bobrow CBE, Department of Medical Genetics, Cambridge Institute for Medical Research and Deputy Chairman of Nuffield Council on Bioethics Professor Tom Baldwin, Department of Philosophy, University of York, member of Nuffield Council on Bioethics Lady Hornby, Chairman of The Kingwood Trust, member of Nuffield Council on Bioethics...

Patient Handbook on Stem Cell Therapies - A Closer Look at Stem ...

W e have all heard about the extraordinary promise that stem cell research holds for the treatment of a wide range of diseases and conditions. However, there is a lot of work still needed to take this research and turn it into safe and effective treatments. The International Society for Stem Cell Research (ISSCR) is very concerned that stem cell therapies are being sold around the world before they have been proven safe and effective. Stem cell therapies are nearly all new and experimental. In these early stages, they may not work, and there may be downsides. Make sure you understand what to look out for before considering a stem cell therapy. Remember, most medical discoveries are based on years of research performed at universities and companies. There is a long process that shows first in laboratory studies and then in clinical research that something is safe and will work. Like a new drug, stem cell therapies must be assessed and meet certain standards before receiving approval from national regulatory bodies to be used to treat people. What does this really mean for you as a patient, doctor, friend or family member? Below we hope to answer some of your questions on stem cells and stem cell therapies and give you the resources you and your doctor need to make the best decisions possible for treatment. The ISSCR is a non-profit professional stem cell research organization with a commitment to ensure the promise of stem cell research is delivered to patients in a safe, effective and fair manner.

Study shows stem cell therapy using a patient's own bone marrow ...

TIME study mirrors Late TIME trial in confirming autologous stem cells obtained from bone marrow are safe but do not further improve the recovery of heart function following a heart attack MINNEAPOLIS, MN – November 6, 2012 – Administering autologous stem cells obtained from bone marrow either 3 or 7 days following a heart attack did not improve heart function six months later, reports a new clinical trial supported by the National Institutes of Health. The results of this trial, called TIME (Transplantation In Myocardial Infarction Evaluation), were presented by Jay Traverse, MD of the Minneapolis Heart Institute Foundation Tuesday, Nov. 6, at the 2012 Scientific Sessions of the American Heart Association in Los Angeles. The results of this trial mirror a previous, related study (LateTIME) which found that autologous bone marrow stem cell therapy given 2-3 weeks after a heart attack did not improve cardiac recovery. Both TIME and LateTIME were carried out by the Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the NIH’s National Heart, Lung, and Blood Institute. “The data presented by TIME do much to advance stem cell therapy research,” said Jay Traverse, MD of the Minneapolis Heart Institute Foundation and Principal Investigator of this study. “While this study did not provide a demonstrated cardiac benefit after six months, we still learned a great deal. Together, TIME and Late TIME have shown that stem cell therapy is safe, and they have set a baseline in terms of quantity of stem cells, type of stem cells, and severity of heart attack.” TIME enrolled 120 volunteers (avg. age 57) between July 2008 and February 2011; the participants all had moderate to severe impairment in their left ventricle and had undergone coronary stent placement as treatment for the heart attack. The participants were randomly assigned to one of four groups: day 3 stem cell, day 3 placebo (inactive cells), day 7 stem cell, or day 7 placebo. The CCTRN researchers developed a method of processing and purifying the stem cells from the bone marrow of each volunteer to ensure everyone received a uniform dose (150 million stem cells)...

2013 Brochure - Carolina Computing Initiative

Why Should I Purchase a CCI Laptop? You’ll want to purchase one of the official CCI Laptops because the laptop packages available to you as an entering UNC-Chapel Hill student are the best value anywhere. Our comprehensive program of hardware, software, and support ensures an unparalleled student computing experience. Only with the purchase of a CCI Laptop will you be eligible for all the programs and services below: • A 4-year Comprehensive Protection Plan including: 4 Years of Manufacturer’s Warranty Coverage 4 Years of Accidental Damage Coverage 4 Years of Laptop Insurance Coverage • Computer Support 24 x 7 • An Award-winning On-campus Repair Center with a pool of loaner laptops • An Extensive Software Package • Security Solutions for keeping your computer and data secured When should I place my order? 8 out of 10 Carolina undergraduates choose a CCI Laptop package to fulfill the laptop requirement. CCI Laptop packages can be ordered through the CCI Website starting in early April. Submit your order by May 15 and your laptop will be waiting for you at your New Student Orientation session this summer. Students admitted after May 15 should order as soon as possible and at least 2 weeks before your New Student Orientation. How do I order my CCI Laptop? [1] Decide which CCI Laptop model you want to purchase [2] Choose Your Printer [3] Choose Your Accessories They will get more than award-winning laptops. They will get support, service, [4] Place Your Order through the CCI website or Call 919-962-8534 Monday-Friday 10am-5pm and software ensuring them an unparalleled student computing experience. How do I pay for my CCI Laptop? [1] Credit Card (Visa, Mastercard or American Express) [2] Laptop grant from the University What if I don’t buy a CCI Laptop? Please note that, while students are not required to purchase a CCI Laptop, students are required to have a laptop that meets the minimum requirements specified. Software and operating system support for non-CCI laptops is on a best-effort basis. Hardware support for non-CCI laptops is the responsibility of the owner. Loaner laptops are only available to students who purchase a CCI Laptop through UNC Student Stores. If you have any additional questions please visit our FAQ...

Apple Price List - Managed Services - New York City Department of ...

NYCDOE, we’re here to help. If you need a little help finding information about Apple products, or if you want to ask about how to get the most out of your Mac, iPad, or iPod, you have a personal team ready to support you. Pre-Sales Questions Delivery and Integration Technical Support General product and pricing inquiries: To check order status: For server and software support: Bob Johnson robertjohnson@apple.com (631) 252-4530 Ashley Loftin SSONYCDOE@apple.com (800) 800-2775, ext. 42691 Tim Brennan tbrennan@apple.com (646) 725-3586 David Nash nash@apple.com (917) 297-5706 To schedule an onsite training or server configuration: For hardware support: Caroline Bruner cbruner@apple.com (800) 800-2775, ext. 42822 Jill Kaufman jkaufman@apple.com (212) 571-1313 Todd Grunow tg@apple.com (718) 935-5639 Allison Salmon asalmon@apple.com (800)800-2775. ext, 42815 Technical systems inquiries: Keith Binder kbinder@apple.com (201)887-6974 NYCDOE Resources: • • • Apple NYCDOE Price List for in your school: FAMIS Portal for DOE-approved Apple item numbers: https://dfoforms.nycenet.edu/FamisPortal/login.aspx Apple Education Licensing Program for the Mac Software Collection MacBook Air 11-inch MacBook Air 13-inch 1.3GHz dual-core Intel Core i5 1.3GHz dual-core Intel Core i5 4GB 1600MHz LPDDR3 memory 4GB 1600MHz LPDDR3 memory 128GB flash storage 256GB flash storage 128GB flash storage 256GB flash storage Intel HD Graphics 5000 Intel HD Graphics 5000 Apple USB SuperDrive (sold separately) Apple USB SuperDrive (sold separately) Built-in lithium-polymer battery Built-in lithium-polymer battery Up to 9 hours of wireless web Up to 12 hours of wireless web One Thunderbolt port, two USB 3 ports One Thunderbolt port, two USB 3 ports, one SDXC card slot 802.11ac Wi-Fi wireless networking; IEEE 802.11a/b/g/n compatible 802.11ac Wi-Fi wireless networking; IEEE 802.11a/b/g/n compatible Bluetooth 4.0 Bluetooth 4.0 Apple USB Ethernet Adapter (sold separately) Apple USB Ethernet Adapter (sold separately) 720p Face Time HD Camera 720p Face Time HD Camera

Associate Director Metro North Regional Employment Board Basic ...

Metro North Regional Employment Board Basic Function Provide overall professional support to the Executive Director and members of the Metro North Regional Employment Board; work with the Executive Director, Board of Directors, and REB members to develop and foster relationships with key stakeholders and to implement REB policies, programs, and initiatives. Assist in the development and implementation of the Metro North strategic plan. Conduct data analysis, research, and evaluation as needed to support workforce development efforts in priority industries. Develop service plans and budgets to ensure successful grant performance. Act as a technical resource to workforce partners and other staff as needed. Assist in or lead efforts to identify and build career pathway tools corresponding to priority industries. Opportunity for growth within the organization for candidate with the right mix of skills and experience. Specific Duties 1. Assist in the development of industry sector partnership groups based on priority industries as identified in the strategic plan; engage partner organizations (employers, training providers/community colleges, career centers, community-based organizations) in these groups; prepare materials, facilitate meetings and provide staff support to industry groups, including preparing meeting summaries. 2. With other REB staff, identify key workforce development issues and opportunities, and research creative approaches/best practices within workforce development nationally, but also across disciplines, with a goal of potentially testing and implementing innovative solutions to workforce development problems. 3. Conduct supporting research, develop and write grant proposals in response to state and federal Requests for Proposals/SGAs; identify and apply for foundation grants to support REB initiatives/industry partnership activities. 4. Develop programmatic plans and budgets to support grant submissions; implement, manage, and track program and budgetary performance of successful submissions. 5. Work closely and effectively with funding sources and with Metro North employers, ...

YMCA of Metro North Camp pre-interview for Camp Counselors.

YMCA of Metro North Camp pre-interview for Camp Counselors. As part of the pre-interview process please answer and submit the following questions below along with your employment application and resume (optional). You can use the provided space or submit typed answers. You can scan and email your paperwork to Gregg Ellenberg at gellenberg@metronorthymca.org or drop them off at the YMCA camp you are applying to. Once your responses are received, we will determine whether we feel that you would be a strong candidate for our camps. If so, we will contact you to set up an interview. Please note that there are mandatory training dates on Saturday, June 14th and Saturday, June 21st (Camp Eastman and Camp Sachem) that are required to work camp for the summer. The safety and well-being of our campers is of utmost importance. Before you can work at the YMCA of Metro North, you must undergo an intensive background check that includes but is not limited to an examination of your criminal history (a CORI and SORI check) and the National Sex Offender Registry; 4 references checked; two in person interviews; several hours of Child Abuse prevention training; and First Aid and CPR/AED certification. If you are not comfortable with this process, please seek employment elsewhere.

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