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Stem Cell Therapy: the ethical issues a discussion paper Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3EG Telephone: Fax: Email: Website: 020 7681 9619 020 7637 1712 firstname.lastname@example.org http://www.nuffieldfoundation.org/bioethics April 2000 © Nuffield Council on Bioethics 2000 All rights reserved. Apart from fair dealing for the purpose of private study, research, criticism or review, no part of the publication may be produced, stored in a retrieval system or transmitted in any form, or by any means, without prior permission of the copyright owners. Nuffield Council on Bioethics Professor Ian Kennedy (Chairman) Professor Martin Bobrow CBE (Deputy Chairman) Professor Tom Baldwin Professor Sir Kenneth Calman KCB FRSE* Reverend Professor Duncan Forrester DD Professor Brian Heap CBE FRS Mrs Rebecca Howard Lady Hornby Professor John Ledingham Mr Derek Osborn CB Professor Catherine Peckham CBE Professor Martin Raff FRS Mr Nick Ross Professor Herbert Sewell Professor Albert Weale FBA * (co-opted member of Council for the period of his Chairmanship of the Working Party on the ethics of healthcare-related research in developing countries) The terms of reference are as follows: 1 to identify and define ethical questions raised by recent advances in biological and medical research in order to respond to, and to anticipate, public concern; 2 to make arrangements for examining and reporting on such questions with a view to promoting public understanding and discussion; this may lead, where needed, to the formulation of new guidelines by the appropriate regulatory or other body; 3 in the light of the outcome of its work, to publish reports; and to make representations, as the Council may judge appropriate. The Nuffield Council on Bioethics is funded jointly by the Medical Research Council, the Nuffield Foundation and the Wellcome Trust Attendees of the Round Table meeting on Stem Cell Therapy: the ethical issues Professor Martin Bobrow CBE, Department of Medical Genetics, Cambridge Institute for Medical Research and Deputy Chairman of Nuffield Council on Bioethics Professor Tom Baldwin, Department of Philosophy, University of York, member of Nuffield Council on Bioethics Lady Hornby, Chairman of The Kingwood Trust, member of Nuffield Council on Bioethics...
Ultrasound is used to precisely guide the injection of adipose-derived stem cells into the suspensory ligament. The still-developing technology of stem cell therapy, which uses unspecified cells from the horse’s body, has the potential to help racehorses heal sounder than ever before. A tendon is a bundle of elastic fibers, mostly made of collagen, that attaches muscle to bone and helps move the skeleton. Ligaments are similar but attach bone to bone and provide stability. When a horse bows a tendon, it tears the fibers at a certain point of the tendon (the location results in a name, such as high or low bow), weakening it significantly. When the tendon begins to knit back together, it is significantly hampered by lack of blood flow. Blood provides several healing mechanisms, including adult stem cells, which are able to convert themselves into specific types of cells the body needs to heal itself (in this case, tendon cells). If the tendon does not get enough help, it eventually develops scar tissue, which weakens the tendon because it is nonelastic and haphazardly knitted together. The injury takes a long time to heal – a typical racetrack cure was pinfiring or blistering, followed by six months to a year of turnout. If a horse was brought back to the track and the tendon had mostly healed with scar tissue, the weakened tendon could give way and the injury recur.
STEM CELLS AND CEREBRAL PALSY Cerebral palsy (CP) is an umbrella term which includes several forms and levels of nonprogressive brain-related injury, which cause limitations in muscle control, movement and mobility (known as neuromotor impairment) and other symptoms that lead to physical disability. CP is caused by many factors, and can include infection before birth, premature birth and lack of oxygen around the time of birth. It is thought that the major common feature in CP is a lack of blood and oxygen to the brain during fetal development and/or delivery, known as a hypoxic-ischemic insult. The cells most vulnerable to this hypoxic-ischemic insult are oligodendrocytes, the support cells that wrap nerve cells (or neurons) with a protective white fat called myelin, hence the term white matter of the brain. Because of this myelin, neurons can send electrical signals efficiently throughout the body. Once oligodendrocytes die, the neurons are no longer protected and they eventually die. If myelin could be replaced before neurons die, neurons could be spared and motor impairments could be lessened. For this reason, scientists are investigating whether lost oligodendrocytes can be replaced with stem cells. Stem cells are unspecialized cells which can become specialized cells such as brain cells, heart cells or muscle cells. The process of developing into a specialized cell is known as differentiation. Stem cells can also multiply over and over again, a process known as proliferation. During the process of proliferation the stem cell either remains unspecialized or, under the right condition, can become a specialized cell such as a brain cell. Replacing neurons themselves would be like trying to rewire a giant switchboard with tens of thousands of ports but no labels, where improper connections could lead to pain. It is for this reason that the aim of many cell transplantation strategies now being tested is to replace lost oligodendrocytes rather than to make and successfully connect new neurons. Recent decades have seen advances in our knowledge of how to study and use stem cells. It is expected we will develop ways to transplant stem cells into damaged tissues to treat and cure injury and diseases like CP. From Mice to Humans...
CAULIFLOWER STEAK >> 1 cauliflower yields approx 3 “steaks” Ingredients: 1 head of cauliflower Olive oil Kosher salt (table salt or sea salt or whatever you have) Pepper Chopped handful of parsley (optional) © Disney Take 1 head of cauliflower and clean off all leaves from the bottom. Cut off the stalk, so that it’s flush with the rest of the cauliflower body. Take the cauliflower and place on its side so that the stalk is in front of you horizontally. Take a sharp knife and cut the cauliflower through its body, so that you are making crosssections of pieces. Once cut, the stalk is in the middle holding all florets together It’s ok if when cutting, some of the florets come loose, you can roast those pieces later. Once you have all your “steaks” cut, place them on a roasting tray. Drizzle with olive oil, salt & pepper and chopped parsley if you have, or even like it! Rub the steaks all over on both sides. Heat BBQ / grill on medium/high heat. Place “steaks” on grill and begin to cook approx 3-5 minutes on each side. They should have nice grill marks on both sides. Once all steaks are done, insert a fork to check that they are tender. Place back on roasting tray and cover with foil, sealing all edges. The heat from the steaks sealed in the foil will continue to cook the steaks until they become nice and tender. That’s it! You’re done! So easy you’re laughing!! DisneyJunior.com/ThatsFresh
For over sixty years, Joe Bowman Auto Plaza has been serving Harrisonburg, Va. and surrounding areas by providing quality new and used automobiles. A Chevrolet- and Cadillac-certified dealer, Joe Bowman Auto Plaza provides the area with a massive inventory, and offers a full-service maintenance and body shop for GM models, as well as a heartfelt commitment to helping people find the vehicles they need with world-class customer service and expertise. Visit http://www.JoeBowmanAutoPlaza.com today for more information. Contact Details: Joe Bowman Auto Plaza 2455 East Market, Harrisonburg, VA 22801 SALES: (540) 908-2803 SERVICE: (540) 908-2809
Product No. EW30ES6CGS6 37663376J76S6 Series 30" elec Color stainless Market Canada Wiring Diagram 318550155 Owner's Guide 318203847 Installation Instructions 318201615 Service Data Sheet 318127078 Quick Start Guide 318203404 30-INCH SLIDE-IN RANGE EW30ES65GS.bmp CEW30ES65GWB.eps BEW30ES6CGS5.eps TEW30ES65GSE.eps ELECTRIC DEW30DS6CGS6.eps 318550155-1.eps 318550155-2.eps Model No. EW30ES6CG Electrolux Major Appliances P.O. BOX 8020 CHARLOTTE, NC 28262 Publication No. 5995581237 10/11/22 (EN/SERVICE/ECL) 377 Publication No: 5995581237 EW30ES6CGS6 BACKGUARD 11/10 2 EW30ES6CGS6 Publication No: 5995581237 BACKGUARD POS. NO 18 19 # 20 # 21 22 23 24 25 97A# 99 # 99*# PART NO. 318900301 318387121 316576612 316524400 318905005 5304417153 5303307980 5303131801 316576432 316535201 318578306 DESCRIPTION Subframe, control Control Assembly, glass, black, w/interface Controller, electronic, ES630 Screw, control mtg, 6-32 x .25, (5) Panel, service, stainless Screw, shoulder, 8-18 X 1/2, (4) Screw, 8-32 x 0.437, (8) Screw, 10 x 3/8 Board, power, UIB Board, power supply, 8V Harness, wiring, power supply * # * # * * 318578320 318578321 318163602 5303211311 Harness, wiring, controller, to UIB Harness, wiring, UIB, to power boards Cleaner, stainless steel Screw, 8-18 x 0.500 # Functional Parts * Non-Illustrated Parts 3 11/10 Publication No: 5995581237 EW30ES6CGS6 BODY 11/10 4 EW30ES6CGS6 Publication No: 5995581237 BODY POS. NO 1 1A 2 3 4 4A 6 6A 6B 7 8 8A 8B 8B* 9 10 11 12 13 13* 14 # * # 15 18 20 21 24 29 37 # 39 # 53 # 54 # 54* 54* 54* 55 58A 58B 58C 58D 59 59* 62 62* 66 # 67 # 70 71 76 77 77A # Functional Parts * Non-Illustrated Parts
NOTES • are must be taken during customer installation of equipment and wiring C to ensure that all holes drilled in the body are corrosion protected, properly sealed and that vehicle wiring harnesses, piping or other components have not been displaced or damaged. Aftermarket equipment installers must be mindful of applicable Federal Motor Vehicle Safety Standards. This information can be obtained directly from the National Highway Traffic Safety Administration. • These vehicles are equipped with an air bag system. The air bag system in your police vehicle includes front seat back, front knee and side curtain air bags. Customer installed equipment such as security barriers behind the front seats should not be mounted so that the barrier ends are within the side air bag deployment zones. The sensors and other components for the air bag system must not be relocated to accommodate the installation of customer furnished equipment; please refer to the service manual for sensor and other component locations. For information concerning instrument panel top pad mounted equipment and air bag system deployment zones, see the air bag information section in this catalog. • This catalog is not updated during the model year and should not be
NOTES ON ALL GENERAL MOTORS HARNESS SYSTEMS We have done a great deal of research on General Motors wiring harnesses in order to provide you with the most authentic wiring systems possible. While doing this research, we had the opportunity to study original harness blueprints and specifications for some General Motors products. All of the data we examined specified that the wire was to have a natural cotton base color (a light tan) braided over the rubber insulation, with tracer colors woven in for wire identification. The tracer colors would consist of a single thread parallel tracer or two single thread crossing tracers, as specified on the harness blueprints. After the cotton braid was applied to the wire it was to be given a protective coating consisting of a heat, oil and water resistant varnish. This protective coating would color with age and cause the original wire to appear dark yellow, orange, or brown. All the wire we use for General Motors vehicles conforms to the original color codes as specified by the manufacturer. One note on our General Motors harness systems: At this time we cannot supply the original type GM twist connectors, the rear body plug, or the turn signal switch plug. We do provide substitute connectors...
Pretty much all all women can begin to play a beautiful, soothing, supple, great coupled with sophisticated facial skin. Having this memorable flesh every one of us all have to choose to stay on the lookout for gorgeous flesh recommendations. As well as like we adult, it is all extra needed to get started with directly by way of a high quality scrub your pores clean programs; once we don't have at the moment succeeded in doing so.Rinse your face two tmes a day. Eliminate rubbing sensitive skin simply because pores of the skin could possibly much more than generate cooking oils. Readily SPF confront cream in order to cleanse see your face. Lotion must be in the old days care for sensitive skin as a result of dryness. Everyone receiving fried surface of the skin do not have to hydrate commonly in the event that compared by way of individuals with dry and fresh, conventional or else merge the skin. Time to incorporate overall body emollient is immediately subsequent a bathroom; mainly bec
Men already know that male organ function depends on so many body functions working together, but few are aware of the role that this nutrient dynamo plays in reproductive health.