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Stem Cell Therapy in a Caprine Model of Osteoarthritis J. Mary Murphy,1 David J. Fink,1 Ernst B. Hunziker,2 and Frank P. Barry1 Objective. To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). Methods. Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA was induced unilaterally in the knee joint of donor animals by complete excision of the medial meniscus and resection of the anterior cruciate ligament. After 6 weeks, a single dose of 10 million autologous cells suspended in a dilute solution of sodium hyaluronan was delivered to the injured knee by direct intraarticular injection. Control animals received sodium hyaluronan alone. Results. In cell-treated joints, there was evidence of marked regeneration of the medial meniscus, and implanted cells were detected in the newly formed tissue. Degeneration of the articular cartilage, osteophytic remodeling, and subchondral sclerosis were reduced in cell-treated joints compared with joints treated with vehicle alone without cells. There was no evidence of repair of the ligament in any of the joints. Conclusion. Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA.
QUALIFYING LOCATIONS: Qualifying Products (as defined below) must be purchased from the U.S. Apple Online Store for Education Individuals, from a U.S. Apple Retail Store, by calling 1-800-MY-APPLE, or from an Apple Authorized Campus Store on the list at www.apple.com/promo/bts/participants.html (collectively, “Qualifying Locations”). iPhone devices must be purchased from Apple; Apple Authorized Campus Store iPhone purchases are not eligible. Only purchases made in the 50 United States or the District of Columbia are eligible. All shipments of Qualifying Products must be made to an address in the 50 United States or the District of Columbia. Orders for Qualifying Products from the U.S. Apple Online Store for Education Individuals or 1-800-MY-APPLE that are placed during the above promotion period and ship after the offer ends are eligible. EDUCATION INDIVIDUAL PURCHASE QUALIFICATIONS: Those eligible to purchase as Education Individuals include faculty, staff, students, and parents as follows: K–12: Any employee of a public or private K–12 institution in the United States is eligible. In addition, school board members who are currently serving as elected or appointed members are eligible. PTA or PTO executives currently serving as elected or appointed officers are eligible. Higher Education: Faculty and staff of higher education institutions; and students attending or accepted into a higher education institution are eligible. Higher Education Parents: Parents purchasing on behalf of their child, who is a student currently attending or accepted into a public or private higher education institution in the United States, are eligible. PRODUCT ELIGIBILITY: Only the following Apple products qualify for this promotion: Qualifying Apple Computers: iMac, MacBook Pro, MacBook Air, and Mac Pro. Qualifying iPhone: iPhone 4, iPhone 4S, and iPhone 5.
• Review this document before taking possession of your MacBook. • The Apple MacBook, power adapter, case, stored data, on campus network and Internet access, and any services that will be issued are the sole property of the Shelton School & Evaluation Center. • The equipment listed is on loan to the student for the period designated on the last page. At the end of the loan period, or upon withdrawal from the school, all equipment must be returned in good working order. • These technologies are on loan to the student and must be used in accordance with all school policies, any applicable laws, and this document. Refer to the Shelton Acceptable Use Policy for Technology in the Parent Handbook. • These technologies are provided for educational and instructional purposes only and are intended to support the learning objectives of the school. • Students and their parents/guardians are responsible for cost of repair or replacement which will be assessed in the event of lost or damaged equipment. • Use of these technologies is a privilege and not a right. Equipment to be issued • Apple MacBook Air 13” • Apple MacBook Air Power adapter • STM Carrying Case (for MacBook Air) Ownership and Installation of Apps • Students are not allowed to install software on their computer without specific permission from the Shelton Technology Department and/or Administration. • Students and parents may purchase software and request that it be installed. Tech Support will require documentation of valid licensing and any license codes or account logins necessary to complete the installation. • Personally purchased software should be appropriate for school and conform to School Policy regarding content. (See the Shelton Acceptable Use Policy for Technology in Parent Handbook). Students/parents retain ownership of personally purchased software but should...
In the context of today’s changing fiscal landscape on both the state and federal level, the Metro North REB is entering a stage of development that is guided by new opportunities as well as challenges. As it moves forward, the REB must identify creative new approaches, consider diverse sources of funding, and streamline existing systems to optimize efficiency. In addition, undertaking a renewed philosophy of continuous improvement and innovation in program implementation will be crucial to adjusting approaches in workforce development to align with the ever-changing economy. Historically, the education and workforce development systems have been only sporadically, marginally, or indirectly connected to business needs. Although some components of the workforce development system (notably community-based training and employment programs), have a long history of aligning their training with strong employer partnerships, the K-12 and college education systems have been grounded in a philosophy of preparing people for life, by providing a broad, general education, and only targeting training to specific occupations later in the post-secondary experience. In addition, education and workforce development have struggled to keep up with changing technologies and trends in industry, often lacking critical information about where career opportunities exist and what skills and abilities are necessary to take advantage of those options. As a result, education and training are often disconnected from real-time employer needs, and as a result, unemployed youth and adults often lack the necessary skills to enter those jobs that do exist, creating a growing class of disconnected or never connected workers.
On May 17, 2013, in Bridgeport, Connecticut, an accident occurred on Metro-North’s New Haven Line, when an eastbound Metro-North train of 8 cars, traveling 74 mph, derailed and came to rest on an adjacent track. Approximately 20 seconds later, a westbound Metro-North train on that adjacent track struck the derailed train. As a result of the accident, more than 50 people, some seriously injured, were hospitalized, rail operations were suspended, and millions in property damage occurred. • On May 28, 2013, a second accident occurred when a Metro-North train in West Haven, Connecticut, that was traveling 70 mph, struck and killed a Metro-North maintenance-ofway (MOW) employee who was part of a roadway work group performing railroad maintenance on a construction project. • On July 18, 2013, a third accident occurred when a CSX Transportation freight train derailed while traveling over Metro-North’s system. No one was injured, but property damage was significant. • On December 1, 2013, the fourth accident occurred when a Metro-North train of 7 cars traveling south from Poughkeepsie, New York, to Grand Central Terminal in New York City, derailed as it approached the Spuyten Duyvil Station. All cars derailed and the front cab came to rest close to the Harlem River. Four passengers were killed, and more than 70 were injured. Rail operations were suspended, and millions of dollars in property damage alone was sustained. On December 3, 2013, 2 days after the fourth and most serious of these accidents, FRA sent a letter to MTA expressing support for Governor Andrew Cuomo’s directive that MTA hold a safety stand-down, and directing Metro-North to implement a Confidential Close Call Reporting System (C3RS) (Appendix 2). Additionally, FRA issued Emergency Order 29 and Safety Advisory 2013-08. • Emergency Order 29, issued on December 6, 2013, required Metro-North to take immediate action to prevent excessive train speeds by identifying and prioritizing highrisk areas, modifying its existing signal system to ensure speed limits are obeyed, and 1 requiring a higher level of engagement and communication among operating crewmembers in areas in which major speed restrictions are in place. • Safety Advisory 2013-08, issued on December 10, 2013, urged railroads to provide additional training, increase the frequency of operational testing, and reinforced the importance of communication between crew members. The purpose was to ensure that all railroads adhere to Federal regulations and railroad operating rules regarding maximum authorized train speed limits. On December 16, 2013, FRA launched Operation Deep Dive, an assessment of Metro-North’s operations and safety compliance. More than 60 technical and human factor experts comprising 14 teams, conducted a 60-day comprehensive safety assessment of Metro-North. With assistance from the Federal Transit Administration, these experts reviewed and assessed Metro-North’s safety-related processes and procedures, its compliance with safety regulations and requirements, and its overall safety culture. In assessing Metro-North, the Deep Dive team evaluated:...
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You can read the recommendations in the user guide, the technical guide or the installation guide for ACER ASPIRE 5315. You'll find the answers to all your questions on the ACER ASPIRE 5315 in the user manual (information, specifications, safety advice, size, accessories, etc.). Detailed instructions for use are in the User's Guide. User manual ACER ASPIRE 5315 User guide ACER ASPIRE 5315 Operating instructions ACER ASPIRE 5315 Instructions for use ACER ASPIRE 5315 Instruction manual ACER ASPIRE 5315 Your user manual ACER ASPIRE 5315 http://mypdfmanuals.com/dref/1115241 Manual abstract: Never spill liquid of any kind onto or into the product. To avoid damage of internal components and to prevent battery leakage, do not place the product on a vibrating surface. Never use it under sporting, exercising, or any vibrating environment which will probably cause unexpected short current or damage rotor devices, HDD, Optical drive, and even exposure risk from lithium battery pack. · · · Using electrical power · This product should be operated from the type of power indicated on the marking label. If you are not sure of the type of power available, consult your dealer or local power company. Do not allow anything to rest on the power cord. Do not locate this product where people will walk on the cord. If an extension cord is used with this product, make sure that the total ampere rating of the equipment plugged into the extension cord does not exceed the extension cord ampere rating. Also, make sure that the total rating of all products plugged into the wall outlet does not exceed the fuse rating. Do not overload a power outlet, strip or receptacle by plugging in too many devices. The overall system load must not exceed 80% of the branch circuit rating. If power strips are used, the load should not exceed 80% of the power strip's input rating. This product's AC adapter is equipped with a three-wire grounded plug. The plug only fits in a grounded power outlet. Make sure the power outlet is properly grounded before inserting the AC adapter plug. Do not insert the plug into a non-grounded power outlet. Contact your electrician for details. · · · · Warning! The grounding pin is a safety feature. Using a power outlet that is not properly grounded may result in electric shock and/or injury.
Changes may be made periodically to the information in this publication without obligation to notify any person of such revisions or changes. Such changes will be incorporated in new editions of this manual or supplementary documents and publications. This company makes no representations or warranties, either expressed or implied, with respect to the contents hereof and specifically disclaims the implied warranties of merchantability or fitness for a particular purpose. Record the model number, serial number, purchase date and place of purchase information in the space provided below. The serial number and model number are recorded on the label affixed to your computer. All correspondence concerning your unit should include the serial number, model number and purchase information. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronically, mechanically, by photocopy, recording or otherwise, without the prior written permission of Acer Incorporated. Aspire 5715Z/5315 Series Notebook PC