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Stem Cell Therapy in a Caprine Model of Osteoarthritis J. Mary Murphy,1 David J. Fink,1 Ernst B. Hunziker,2 and Frank P. Barry1 Objective. To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). Methods. Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA was induced unilaterally in the knee joint of donor animals by complete excision of the medial meniscus and resection of the anterior cruciate ligament. After 6 weeks, a single dose of 10 million autologous cells suspended in a dilute solution of sodium hyaluronan was delivered to the injured knee by direct intraarticular injection. Control animals received sodium hyaluronan alone. Results. In cell-treated joints, there was evidence of marked regeneration of the medial meniscus, and implanted cells were detected in the newly formed tissue. Degeneration of the articular cartilage, osteophytic remodeling, and subchondral sclerosis were reduced in cell-treated joints compared with joints treated with vehicle alone without cells. There was no evidence of repair of the ligament in any of the joints. Conclusion. Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA.
When selecting a high-end portable workstation for multimedia creation and viewing, performance counts. Large files and complex applications can slow systems with limited amounts of RAM or basic graphic cards. Those who invest in a system with a powerful 4th generation Intel® Core™ i7 processor, 16 GB of RAM, and two heavy-duty graphics cards do so because their compute-intensive workloads require such hardware. In our labs, we tested three current high-end portable systems, a 4th generation Intel Core processor-based Dell Precision M3800 with QHD+ touchscreen display, a similarly configured 2013 Apple MacBook Pro with Retina display, and a 2012 Apple MacBook Pro with Retina display, to see how well they performed. While the systems were comparably configured, the Dell Precision M3800 has a touch screen and runs Windows 8.1, allowing users to select, zoom, and edit their work right on the screen. It also has three times the storage capacity of the 2012 MacBook Pro and 33 percent more than the 2013 MacBook Pro, which is very useful for storing large multimedia files. The Dell Precision M3800 outperformed both MacBook Pro systems on several tests. Along with its $2,249 purchase price, which is 13.5 percent lower than that of the 2013 MacBook Pro, these advantages make the Dell Precision M3800 an excellent choice for those who work with multimedia content and need an extremely powerful system they can use at the office and on the go.
Joint science academies’ statement: Global response to climate change Climate change is real There will always be uncertainty in understanding a system as complex as the world’s climate. However there is now strong evidence that significant global warming is occurring1. The evidence comes from direct measurements of rising surface air temperatures and subsurface ocean temperatures and from phenomena such as increases in average global sea levels, retreating glaciers, and changes to many physical and biological systems. It is likely that most of the warming in recent decades can be attributed to human activities (IPCC 2001)2. This warming has already led to changes in the Earth's climate. The existence of greenhouse gases in the atmosphere is vital to life on Earth – in their absence average temperatures would be about 30 centigrade degrees lower than they are today. But human activities are now causing atmospheric concentrations of greenhouse gases – including carbon dioxide, methane, tropospheric ozone, and nitrous oxide – to rise well above pre-industrial levels. Carbon dioxide levels have increased from 280 ppm in 1750 to over 375 ppm today – higher than any previous levels that can be reliably measured (i.e. in the last 420,000 years). Increasing greenhouse gases are causing temperatures to rise; the Earth’s surface warmed by approximately 0.6 centigrade degrees over the twentieth century. The Intergovernmental Panel on Climate Change (IPCC) projected that the average global surface temperatures will continue to increase to between 1.4 centigrade degrees and 5.8 centigrade degrees above 1990 levels, by 2100.
Technical Analysis – Fibonacci Levels Retracements A retracement is a pullback within the context of a trend. Dip After a rise from 0 to 1, short term market participants start to take profit. This drives the price lower until such a point that the bulls, sensing the price is better value, enter the market again at point 2 and hence “Buy the Dip” enabling the market to continue in the direction of the trend. Rally Conversely, after a fall from 0 to 1, the shorts take profits thus causing a brief rally taking the price higher until point 2. At point 2, fresh shorts enter the market overcoming the shorter term bulls and driving the price lower in the direction of the main trend. Hence the term “Sell on Rally”. The most popular type of retracement used in the Forex market is, undoubtedly, the Fibonacci retracement. Popular Fibonacci retracements are 25%, 38.2%, 50%, 61.2% and 78.6%. Notice how the downleg retraces 61.8% of the first upleg, 1.2970-1.3470, before continuing with the trend upwards. In general, the larger retracements are found at the start and end of a trend as the market is deciding whether or not the previous trend has finished, maybe ranging a little before starting the next trend. Once more and more market participants realise that a new trend is in place, the retracements of the previous leg become smaller in depth with 38.2% and 50% being the most common. As the trend appears to run out of steam, the market becomes undecided and starts to take profit thus causing a deeper retracement of the previous leg eg. 61.8% or 78.6% In a trending market, the shallower the retracement the stronger the trend. Extensions Extensions are used to project where a price may go to and are useful for calculating target prices when entering a trade As with retracements, the most popular type of extension used in the Forex market is the Fibonacci extension. The extensions that provide the most commonly used projections are 61.8%, 100%, 161.8% and 261.8% How to Use In the example below, each one of the Fibonacci extensions represents a potential target when entering a trade. Once a pullback is in place at point 2, we can calculate the potential targets using Fibonacci extensions. Our initial targets will be 100% at 103.85 and 161.8% at 104.78. Further out our target will be 261.8% at 106.28. The stronger the trend, the greater the chance that the targets will be achieved. www.fibbinarchie.com
Junos Pulse for Samsung GALAXY Mobile Devices Securely Connect, Protect, and Manage Samsung Android-Based GALAXY Mobile Devices Accessing the Corporate Network and Cloud In today’s world, mobile devices and their applications are ubiquitous for personal and corporate use. Mobile device users around the globe simply expect to connect from any Challenge Samsung offers a broad range of mobile devices globally, and organizations have users who want to use their personal Samsung GALAXY mobile devices for work, as well as for their personal needs, It is essential that IT departments can secure these mobile devices. Solution Juniper Networks Junos Pulse and its Junos Pulse Mobile Security Suite deliver secure, mobile remote access, comprehensive mobile device security, and device and application management, enabling organizations to comfortably deploy and secure personal or corporate-issued Samsung GALAXY mobile devices. Benefits • Fast, secure connectivity via SSL VPN remote access and differentiated security posture-based access • Advanced, heuristics-based mobile antimalware • Mobile device and application management, including loss and theft protection, and backup and restore • Automatic removal of malicious applications, and administrative revocation of unwanted applications without requiring user intervention (unique to Samsung GALAXY)
Welcome & Congratulations Congratulations on your purchase of a new range! At Electrolux Home Products, we are very proud of our product and are completely committed to providing you with the best service possible. Your satisfaction is our number one priority. We know you’ll enjoy your new range and Thank You for choosing our product. We hope you consider us for future purchases. PLEASE CAREFULLY READ AND SAVE THESE INSTRUCTIONS This Use & Care Manual provides specific operating instructions for your model. Use your appliance only as instructed in this manual. These instructions are not meant to cover every possible condition or situation that may occur. Common sense & caution must be practiced when installing, operating & maintaining any appliance. Please record your model and serial numbers below for future reference. Model Number: Serial Number: Serial plate is located behind the broil or storage drawer on the lower right side of the appliance frame. Purchase Date: This Use & Care Manual contains general operating instructions for your appliance and feature information for several models. Your range may not have all the described features. The graphics shown are representative. The graphics on your range may not look exactly like those shown. Product Registration Be sure to register your product. The self-addressed PRODUCT REGISTRATION CARD should be filled in completely, signed and returned to Electrolux Home Products.
Getting started - Week 9 Good going – you’ve made it to Week 9! We hope keeping track of your calories is becoming easier. If you started the Couch to 5K running plan on Week 2, you should be just one week from graduation! If you’re still working towards 150 minutes of activity a week, keep going! We know you can do it! Just keep doing a little bit more each week. Let’s give it a big push this week. The key is to do something you enjoy that can fit into your routine. Your actions for Week 9 • Go to the weight loss forum to find out what other people are doing to raise their activity levels • If you’re lacking motivation, use the What’s Your Sport tool to find out what activity suits you best • Have a go at this week’s recipe, which should satisfy any sweet cravings. If it’s not your cup of tea – research some different lower-calorie recipes Laura’s diary Week 9 How’s the exercise regime going? Whether you’re struggling or you’ve taken to it like a duck to water, I can’t recommend the forums enough. They are truly inspiring and full of people who’ve found their own way of making it work for them. Exercise is a really important habit to learn not just for the purposes of this 12-week guide but for the rest of your life. Think about ways you can support yourself in...
Cereal Chem. 67(5):448-451 Temperature profiles and quality characteristics (batter specific gravity, weight loss, cross-sectional area, and symmetry) were evaluated in a lean cake formulation heated by microwave and conventional energy in metal and glass baking pans for the purpose of choosing one pan type for future studies. The statistical results showed that cakes baked in glass pans in microwave and conventional ovens had more similar crosssectional areas and weight losses than their metal pan counterparts. Also, temperature profiles showed hottest edges and coolest centers for cakes baked in glass pans in both oven types. Cake quality is influenced by pan size and shape and by pan materials (Charley 1950, 1952, 1956; Toledo 1980.) For example, a shallow cake often results in a better quality layer cake (Charley 1952). Cake volume was higher when dark, dull pans composed of steel, japanned iron, or anodized aluminum were used, and it was lower in shiny aluminum, tinned iron, stainless steel, and copper pans (Charley 1950, 1952). Also, the heat transfer characteristics were different in glass than in metal pans. Glass pans...
DuPont™ Vespel® CR-6100 APPLICATION AND INSTALLATION GUIDE FOR CENTRIFUGAL PUMP STATIONARY WEAR PARTS Fluid processing industries have embraced the use of composite materials in pumps to reduce vibration, increase mechanical seal life and MTBR (mean time between repair), reduce the risk of seizure, increase efficiency, and reduce repair costs. API 610, 10th Edition (ISO standard 13709), the latest centrifugal pump standard from the American Petroleum Institute (API), recognizes the use of composites to achieve these benefits. The function of wear rings Wear rings are installed with close radial clearances and separate rotating and stationary, higher and lower-pressure sections of a pump. When shaft deflection occurs due to off-design operation, Background wear rings can experience contact. Historically, wear rings have The CR-6100 grade of DuPont Vespel parts and shapes is a been made from metal, which can gall and seize the pump composite material consisting of carbon fibers held in a Teflon® under contacting or run-dry conditions, resulting in abrupt, high- fluorocarbon resin matrix (PFA/CF Reinforced Composite, energy pump failure. With metal wear rings, design clearance 20 wt% random x-y oriented carbon-fiber). Vespel® CR-6100 has is increased to prevent failure, which has a negative effect on been installed in thousands of pumps in refineries, chemical efficiency, suction conditions, and overall pump vibration. Vespel® plants, power plants, and other fluid processing facilities since CR-6100 can be installed with reduced clearances, without 1996. It has replaced metal and other composite materials used increasing the risk of seizure while improving pump performance.