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TIME study mirrors Late TIME trial in confirming autologous stem cells obtained from bone marrow are safe but do not further improve the recovery of heart function following a heart attack MINNEAPOLIS, MN – November 6, 2012 – Administering autologous stem cells obtained from bone marrow either 3 or 7 days following a heart attack did not improve heart function six months later, reports a new clinical trial supported by the National Institutes of Health. The results of this trial, called TIME (Transplantation In Myocardial Infarction Evaluation), were presented by Jay Traverse, MD of the Minneapolis Heart Institute Foundation Tuesday, Nov. 6, at the 2012 Scientific Sessions of the American Heart Association in Los Angeles. The results of this trial mirror a previous, related study (LateTIME) which found that autologous bone marrow stem cell therapy given 2-3 weeks after a heart attack did not improve cardiac recovery. Both TIME and LateTIME were carried out by the Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the NIH’s National Heart, Lung, and Blood Institute. “The data presented by TIME do much to advance stem cell therapy research,” said Jay Traverse, MD of the Minneapolis Heart Institute Foundation and Principal Investigator of this study. “While this study did not provide a demonstrated cardiac benefit after six months, we still learned a great deal. Together, TIME and Late TIME have shown that stem cell therapy is safe, and they have set a baseline in terms of quantity of stem cells, type of stem cells, and severity of heart attack.” TIME enrolled 120 volunteers (avg. age 57) between July 2008 and February 2011; the participants all had moderate to severe impairment in their left ventricle and had undergone coronary stent placement as treatment for the heart attack. The participants were randomly assigned to one of four groups: day 3 stem cell, day 3 placebo (inactive cells), day 7 stem cell, or day 7 placebo. The CCTRN researchers developed a method of processing and purifying the stem cells from the bone marrow of each volunteer to ensure everyone received a uniform dose (150 million stem cells)...
Worktops have a big part in the appearance of the kitchen. They're fundamentally the center of attraction in the area. You may modify or pick solid surface worktops that has the size and shape you'll need. A vital principle to take into account in picking solid surface worktops is that the size has to be simply enough for the kitchen area. It must not be very big or very small otherwise, moving around will be challenging.
specializing in “AIR CONDITIONING, PARTS AND SYSTEMS” for your classic vehicle “PERFECT FIT SERIES” IN-DASH HEAT/ COOL/ DEFROST 1955 - 1956 CHEVROLET SEDAN WITH DELUXE CONTROLS CONTROL & OPERATING INSTRUCTIONS The controls on your new “Perfect Fit” system. Offers complete comfort capabilities in virtually every driving condition. This includes Temperature control in all of the modes. This system also provides DEHUMIDIFICATION in the defrost mode and the ability to blend the air between Face, Heat, and Defrost modes. FAN SPEED FACE DOOR TEMPERATURE LEVER HEAT / DEFROST DOOR 1 THE PICTURE YOU SEE ON THE FIRST PAGE SHOWS THE CONTROLS IN THE HEAT MODE. THIS MEANS THAT THE AIR WILL BE DISTRIBUTED THROUGH THE HEATER OUTLETS. THIS ALSO HAS THE TEMPERATURE LEVER IN THE COLDEST POSITION. WITH THE CONTROLS IN THIS POSITION YOU WILL GET THE AIR THROUGH THE HEATER OUTLETS AND THE OUTLET TEMPERATURE AT THE COLDEST POSIBBLE DEGREE. CAUTION: ALL OF THE OUTSIDE VENTS MUST BE CLOSED WHEN THE SYSTEM IS IN THE A/C MODE. THIS WILL ALLOW THE A/C SYSTEM TO FUCTION AT ITS MAXIMUM PERFORMANCE LEVEL.
WESTERN PRODUCTS, P.O. BOX 245038, MILWAUKEE, WI 53224-9538 Lit. No. 64127 October 31, 2003 CHEVY/GMC 1500/2500/3500 4x4 1999 & LATER VEHICLE SPECIFIC ELECTRICAL INSTALLATION INSTRUCTIONS Model No. 3515 & 3525 and Model No. 3519 & 3529 Straight Blade (Models 3515, 3525, 3519, & 3529) 2003 & Later: Harness Kit No. 64077 (HB-3 & HB-4 QUAD Lights) Headlamp Kit 12-Pin (White) No. 64078 1999-2002: Harness Kit No. 63392 (HB-3 & HB-4 QUAD Lights) Headlamp Kit 9-Pin No. 61540-1 MVP® Blade (Models 3525 & 3529) 2003 & Later: Harness Kit No. 64085 (HB-3 & HB-4 QUAD Lights) Headlamp Kit 12-Pin (White) No. 64078 1999-2002: Plug-In Harness 63394 (HB-3 & HB-4 QUAD Lights) Headlamp Kit 66640-1 MVP 12-Pin CAUTION Read this document before installing the snowplow. CAUTION See your WESTERN outlet for application recommendations. The Selection List has specific vehicle and snowplow requirements. ®
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More trucks are driven to adventure with LEER caps than any other brand. Great looking LEER caps secure cargo so you can stow and go with the best combination of style, function, value and fit! Aerodynamically engineered LEER caps integrate cleanly with the body lines of your truck. Choose from the widest selection of options in the industry to fit today’s active lifestyles. 100XQ Silverado Extended Cab Short Bed 100XQ Colorado Crew Cab Short Bed www.leer.com Our premium cap features a frameless hidden hinge rear door, easy operating LEER twist handle, standard headliner and one-piece tip-out side windows designed for smooth integration with your truck’s body style. 100XQ Sierra Crew Cab Short Bed 100XQ Silverado HD Crew Cab Short Bed DRIVEN TO EXCEL... LEER ADVANTAGES ■ TRIMLESS EDGES Shaping, sanding and painting the truck cap edge takes more care and time than just covering it up with a vinyl trim strip - but the look is MUCH better! Ask about LEER caps with trimless, finished edges. ■ SKIRTED SIDES COVER BED RAIL CAPS Most LEER models cover the plastic bed rail caps installed by the factory on some new trucks. That means the side view of your truck is visually united in style and color, with no plastic rail cap showing. ■ FIBERGLASS BASE RAILS A structurally superior way to mount a LEER cap on your truck. The rails are integrally molded to the entire length of the cap. Unlike others who just screw or rivet rails to the cap, our method makes the cap a solid, one-piece unit.
2014 Chevrolet Silverado/GMC Sierra Body 1500 Cab Structure Review Thomas Grabowski General Motors Company www.autosteel.org Vehicle Introduction–Chevrolet Silverado Silverado’s exterior design blends strong Chevy truck heritage with a refined, modern aesthetic… Hauling goods since 1918… www.autosteel.org Vehicle Introduction – GMC Sierra GMC designers approached the exterior with respect for its predecessors, evolving its familiar shape while adding distinctive details… A century of truck production… www.autosteel.org High-level Changes From Current Truck www.autosteel.org High-level Changes From Current Truck • Improved Noise and Vibration performance • New inset door design – Triple seal system, reduced wind noise 2013 rear door opening 2014 rear door opening www.autosteel.org
Sleek styling designed for SUV / CUV vehicles 5" Low profile SuperGrippy™, non-slip UV step pads Polished stainless steel Bar lengths for popular CUVs with brackets sold separately Limited Lifetime Warranty 08-13 08-13 08-13 08-13 2013 12-13 12-13 10-13 2013 05-12 Buick Enclave Chevrolet Traverse GMC Acadia Dodge Journey Ford Escape Ford Explorer Honda CR-V Jeep Grand Cherokee Toyota RAV4 Toyota RAV4 Brackets 391715 391715 391715 390215 392675 392705 393945 392445 392865 391865 Bars 395756 395756 395716 395756 395676 395756 395676 395716 395676 395676 RUNNING BOARDS FOR SUV/CUVs 5" WIDESIDER PLATINUM LOW PROFILE BARS for SUV and CUV Applications RUNNING BOARDS FOR CROSSOVERS Black/Black ▪▪ ▪▪ ▪▪ ▪▪ ▪▪ ▪▪ Lightweight aluminum powder coated frame Full-length protective accent trim Slip resistant raised rubber grommets on the step area No-drill installation NRT™ powder coated Mounting Brackets (Sold Separately) Limited Lifetime Warranty
THE PERFECT OIL CHANGE The “Perfect Oil Change” is the easiest thing in the world to do. The problem is that oil changes are often seen as a chore, and the necessary time and attention are often skimped in the rush to get to something that seems more important. You may well be the first owner of the tractor to do this right. The first step is to get the motor good and hot. Run it for at least a half-hour, until the cylinder head is too hot to touch and the oil filter can is uncomfortably warm. This ensures that the oil is hot, which makes it flow easier, and it also makes sure that any crud in the oil is fully entrained and will come out with it. Park it, shut it off, and immediately remove the drain plug on the underside of the engine. Have a drain pan that will hold 6 quarts of oil under the drain. You’ll get a hot, oily hand, because the drain hole is big and most of the oil will come out in one big rush. Once that is draining, turn to the oil filter can, on the left side of the engine. Remove the cap by undoing the big hexagon bolt on the top. Don’t remove the filter yet. Next, locate the drain plug for the filter can – it’s on the bottom of the can, towards the front. It may have a hexagon head, or it may have a square head – either way, it’s usually all boogered up from people using pliers to remove it. Remove it, with a drain pan under the hole – this will allow the oil in the filter can to drain out. Now – go away and leave it alone. Find something else to do, but leave it to drain for at least an hour,...
Changing the sixth generation Corvette Oil Difficulty: 2 out of 5. Time required: Plan on about 1.5 hours taking your time. Tools required: Ramps, Floor jack, Jack stand(s), 13mm wrench or socket, Oil filter wrench, lifting puck, wheel stops, shop rag. Materials required: 1 compatible oil filter, 6 quarts of compatible oil. Capacities are 5.5 Quarts with a filter change for the non-Z51 and 6 quarts with a filter change on the cars with the RPO Z51. Recommended oil is Mobil 1 fully synthetic 5W-30 (GM spec 4718M). Recommended Oil filter is GM UPF44 (2005), UPF46 (2006) UPF48 (2007-2009) If you have access to a lift you can skip to step 6. If you are doing this at home without access to a lift continue to the photos below. Step 1. Get the car up in the air. I use a couple of 2x4’s and my rhino ramps. The 2x4’s will give enough clearance to get up on the Rhino ramps without deflecting the side air dams. Step 2. Get yourself a little more clearance on the driver’s side for easier access to the oil drain plug and filter. Once I have the car up on the ramps I take my floor jack and jacking puck and raise the drivers side further. Don’t forget to block the rear tires once you have the car up on the ramp. Step 3. Get yourself some extra room. Once the jack is in place and the car is up out of the way I will turn the ramp around so that you have easy access behind the tire. Step 4. Place a jack stand up front under the frame support and lower the car back down. Now that the car is lifted and safely supported you can begin the process of changing out the oil. Step 5. Place your oil pan under the drain plug. I like to use a piece of cardboard under the drain pan to collect any oil that may miss the pan during the process of removing the...