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When a ﬂow is driven through a deformable channel or tube, interactions between ﬂuid-mechanical and elastic forces can lead to a variety of biologically signiﬁcant phenomena, including nonlinear pressure-drop/ﬂow-rate relations, wave propagation, and the generation of instabilities. Understanding the physical origin and nature of these phenomena remains a signiﬁcant experimental, analytical, and computational challenge, involving unsteady ﬂows at low or high Reynolds numbers, large-amplitude ﬂuid-structure interactions, free-surface ﬂows, and intrinsically 2D or 3D motion. Whereas frequently the internal ﬂow involves a single ﬂuid phase (albeit often of a complex biological ﬂuid such as blood), in many instances the presence of two or more distinct ﬂowing phases is of primary importance (as is the case for air-liquid ﬂows in peripheral lung airways, for example). We divide this review accordingly: Section 2 treats single-phase ﬂows in collapsible tubes, Section 3 covers recent applications of such ﬂows to a wide range of physiological 0066-4189/04/0115-0121$14.00
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W e have all heard about the extraordinary promise that stem cell research holds for the treatment of a wide range of diseases and conditions. However, there is a lot of work still needed to take this research and turn it into safe and effective treatments. The International Society for Stem Cell Research (ISSCR) is very concerned that stem cell therapies are being sold around the world before they have been proven safe and effective. Stem cell therapies are nearly all new and experimental. In these early stages, they may not work, and there may be downsides. Make sure you understand what to look out for before considering a stem cell therapy. Remember, most medical discoveries are based on years of research performed at universities and companies. There is a long process that shows first in laboratory studies and then in clinical research that something is safe and will work. Like a new drug, stem cell therapies must be assessed and meet certain standards before receiving approval from national regulatory bodies to be used to treat people. What does this really mean for you as a patient, doctor, friend or family member? Below we hope to answer some of your questions on stem cells and stem cell therapies and give you the resources you and your doctor need to make the best decisions possible for treatment. The ISSCR is a non-profit professional stem cell research organization with a commitment to ensure the promise of stem cell research is delivered to patients in a safe, effective and fair manner.
Read these instructions. Keep these instructions. Heed all warnings. Follow all instructions. Do not use this apparatus near water. Clean only with dry cloth. Do not block any ventilation openings. Install in accordance with manufacturer’s instructions. Do not push objects into apparatus vents or slots because fire or electric shock hazards could result. Maintain a minimum distance of at least 6 inches around apparatus for sufficient ventilation. Ventilation should not be impeded by covering the ventilation openings with items, such as newspapers, table clothes, curtains, etc. No naked (open) flame sources, such as lighted candles, should be placed on or near the apparatus. Place apparatus in a stable location so it will not fall causing product damage or bodily harm. Do not install near any heat sources such as radiators, heat registers, stoves, or other apparatus (including amplifiers) that produce heat. Do not defeat the safety purpose of the polarized plug. A polarized plug has two blades with one wider than the other. The wide blade is provided for your safety. If the provided plug does not fit into your outlet, consult an electrician for replacement of the obsolete outlet. • Operate the appartus only from the low level audio line output jack of the computer or of an audio device. • Protect the power cord from being walked on or pinched particularly at plugs, convenience receptacles, and the point where they exit from the apparatus. • Only use attachments/accessories specified by the manufacturer. • Unplug this apparatus during lightning storms or when unused for long periods of time. • Refer all servicing to qualified service personnel.
Read these instructions. Keep these instructions. Heed all warnings. Follow all instructions. Unplug the speakers from the computer and from the electrical outlet before cleaning them with a dry cloth. Install in accordance with the manufacturer’s instructions. Place the speakers in a stable location so they will not fall causing damage to the speakers or bodily harm. Do not use the speakers near water, and do not immerse them in any liquid or pour any liquid on them. Do not block the openings in the speaker cabinets, never push objects into speaker vents or slots because of fire or electric shock hazards, and provide sufficient space around the speakers for proper ventilation. Do not install near any heat sources such as radiators, heat registers, stoves, or other apparatus (including amplifiers) that produce heat. Do not defeat the safety purpose of the polarized plug. A polarized plug has two blades with one wider than the other. The wide blade is provided for your safety. If the provided plug does not fit into your outlet, consult an electrician for replacement of the obsolete outlet. • Operate the speakers only from the audio line out jack of the computer or of an audio device. • Protect the power cord from being walked on or pinched particularly at plugs, convenience receptacles, and the point where they exit from the apparatus. • Only use attachments/accessories specified by the manufacturer. • For added protection during lightning storms, unplug the speakers from the electrical outlet and turn off the computer. • Unplug this apparatus when unused for long periods of time.