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Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem Cell Study for the Treatment of Diabetic Foot Ulcers Grafix closes three times as many wounds as standard of care - the largest relative improvement ever reported in a multi-center, randomized, controlled clinical trial for DFU COLUMBIA, Md. - August 13,2013 - Osiris Therapeutics, Inc. (NASDAQ: OSIR), reported today that its multicenter, randomized, controlled clinical trial comparing the safety and effectiveness of Grafix® to standard of care in patients with chronic diabetic foot ulcers had met the pre-specified stopping rules for overwhelming efficacy as determined by the data monitoring committee during a planned interim analysis. For the primary endpoint, 62% of patients receiving Grafix had complete wound closure compared to only 21% (p<0.0001) of patients who received conventional treatment for their wounds - a relative improvement of 191% and the largest ever reported from such a study. A total of 131 patients were enrolled with the interim analysis being conducted on the first 97 to complete the trial. The trial also reached statistical significance in favor of Grafix on all top-line secondary endpoints, demonstrating faster wound closure and a reduction in the number of treatments needed to achieve wound closure. In the crossover phase of the trial, patients whose wounds failed to close after 12 weeks of standard of care had an 80% closure rate when switched to Grafix. Importantly, patients randomized to receive standard of care were 74% more likely to experience an adverse event than those receiving Grafix (p=0.008). As a result, the blinded phase of the trial is being discontinued immediately and all patients randomized to the control arm will be offered treatment with Grafix. “Today, Osiris has established a new standard in diabetic wound care and has demonstrated to the world the tremendous impact stem cell products can have in medicine,” said C. Randal Mills, Ph.D., Chief Executive Officer. “Diabetic foot ulcers afflict 25% of all diabetics and are responsible for more hospitalizations than any other diabetic complication. With 25 million diabetics in the United States, the cost to our health care system is enormous. Through this rigorous study we have shown that Grafix can heal more patients, in less time, and with fewer complications.”
TRAILERING GUIDE G M C T R A I L er I N G G U I D E capabilities you can count on Engineering Professional Grade trucks, SUVs, crossovers and vans isn't easy. At GMC, we bring some incredible technologies together to build precision-crafted vehicles that exceed expectations. Our latest example? The all-new 2014 Sierra 1500. Everything about it proves that Sierra is more than just a truck. It's incredible thinking in the form of a truck. The following pages will introduce you to Sierra and the rest of our 2014 lineup. TABLE OF CONTENTS 3 _ Selecting a vehic le 5 _ VEHICLES AND HITC HES 7 _ Power and Performa nce 9 _ Tr ailering Terms 10 _ drive t y pes 11 _ TR AILERING ON THE ROAD 12 _ DINGHY TOW ING capABI LIT Y 13 _ SIERR A Tr ai ler Weight Rati ngs 17 _ YUKO N AND TERR AI N Tr ai ler Weight Rati ngs 19 _ ACADIA AND SAVANA Tr ai l er Weight Rati ngs 2 GMC SIERRA 3500HD CREW CAB in QUICKSILVER METALLIC shown with available equipment. T R A I L er I N G G U I D E Selecting A vehicle Every GMC truck, crossover, SUV and van is designed specifically for trailering, with power, handling and convenience features you can rely on for long hauls and heavy loads. This guide will help you select the GMC model that’s right for your trailering needs and also contains helpful tips for loading, driving and parking with your trailer. 3 SIERRA 2500hd crew cab slt in onyx black shown with available equipment. T R A I L er I N G G U I D E maximum trailer weight rating (lbs) 1 The chart below gives you an idea of the maximum amount of weight you can confidently and safely trailer with different GMC model lines when your vehicle is properly equipped. When determining the total weight of trailer and cargo, include the weight of any additional passengers and optional equipment (driver weight and base equipment are already included). See pages 13-19 for maximum trailer weight ratings by specific model.
This brochure is as comprehensive as possible. Though, as some information may have been updated since the time of printing, we reserve the right to make changes at any time, without notice, in colors, materials, equipment, specifications, option packages and model availability. Please contact your nearest GMC dealer for complete details. gmcarabia.com ACADIA/ ACADIA DENALI INNOVATION TO ACHIEVE MORE When you say Denali, think of a proven level of design and craftsmanship that today is at the pinnacle of GMC engineering. The 2013 Acadia Denali: combining premium materials, distinctive style and advanced technologies, it stands as the premier choice in the crossover category. Arriving with a more commanding all-round look, the 2013 Acadia Denali is a product of what you want and what you need. Style intertwined with luxury and power. Keeping Acadia Denali firmly in sight, energy-efficient High Intensity Discharge (HID) beams and LED daytime running lamps increase visibility, while affording a jewel-like necklace of illumination. And, of course, a brand-new signature honeycomb grille is unique to the Denali series and bolder in appeal. At the rear, a pair of chrome outlets has been introduced for a sleek dual flowthrough design, while the rear glass provides a clean and streamlined look.
W ith its reputation for comfort, performance and efficiency, GMC Acadia has remained a popular choice since it was introduced as the brand’s first crossover SUV in 2007. Its luxury-minded Denali model, which came to market in mid-2010, has widened this midsize crossover’s appeal to customers looking for a high level of style, power and functionality. In 2014, the Acadia focuses on safety with the addition of Forward Collision Alert and Lane Departure Warning, crash-avoidance systems that use a camera and sensors to help detect when the driver is getting too close to a vehicle ahead, or when the vehicle enters another lane without the use of a turn signal. The systems alert the driver with visual cues on the dashboard, as well as audible signals. They complement Side Blind Zone Alert and Cross Traffic Alert, which were added in 2013. The camera technology was recently named a “Top Ten Tech Breakthrough of 2012” by Popular Mechanics. The new model year also brings an additional convenience feature: two charging-only USB ports on the rear of the center console to power up electronics ...
Support de Cours Revit Architecture 2014 Ce manuel convient également aux personnes possédant Autodesk Revit 2014 contenu dans les Building Design Suites Réalisez votre projet d’Architecture de A à Z Didacticiel + DVD d’exercices ZA de l’Observatoire - 4, avenue des Trois Peuples - 78180 Montigny-le-Bretonneux N° de déclaration d’existence : 11780231378 - www.aricad.fr - firstname.lastname@example.org Tél. : 01 39 44 18 18 - Fax : 01 30 57 58 85 AriCad (siège) AriCad Paris ZA de l'Observatoire 4, avenue des Trois Peuples 78180 Montigny-le-Bretonneux Tél. : 01 39 44 18 18 Fax : 01 30 57 58 85 5, rue de Surène 75008 Paris Tél. : 01 70 42 80 39 Fax : 01 30 57 58 85 AriCad Nancy AriCad Bordeaux 8, rue Albert Einstein 54320 Maxeville Tél. : 03 83 54 64 22 Fax : 01 30 57 58 85 24, quai Wilson 33130 Bègles Tél. : 05 56 85 66 98 Fax : 01 30 57 58 85 AriCad Strasbourg AriCad Saint-Étienne Immeuble Le Vega 5, rue de Dublin 67300 Schiltigheim Tél. : 03 88 79 90 91 Fax : 03 88 40 01 75 Immeuble POLYGONE 46, rue de la Télématique 42000 Saint-Etienne Tél. : 04 77 92 25 70 Fax : 04 77 79 28 86 AriCad Tarbes AriCad Normandie 62, rue André Fourcade 65000 TARBES Tél. : 05 62 34 52 71 Fax : 05 62 93 72 86 Parc d'Activités de la Bretèque 87, rue Louis Blériot 76230 Bois Guillaume Tél. : 02 32 19 13 79 Fax : 01 30 57 58 85 AriCad Aix-en-Provence Antenne de Nantes 1, rue Mahatma Gandhi «Le Decisium» B2 13090 Aix-en-Provence Tél. 04 42 20 02 88 Fax : 01 30 57 58 85 Antenne de Mulhouse © AriCad Formation 2013 Antenne de Toulouse Support de formation Autodesk® Revit® 2014
2004-2006 Moto Guzzi Breva 750 Installation Instructions Parts List Button Adjustment Display Power Commander USB Cable CD-ROM Installation Guide Power Adapter Power Commander Decals Dynojet Decals Velcro® Strip Alcohol Swab Faceplate Buttons O2 Optimizer 1 1 1 1 1 2 2 2 1 1 Expansion Port USB Port The ignition MUST be turned OFF before installation! You can also download the Power Commander software and latest maps from our web site at: www.powercommander.com PLEASE READ ALL DIRECTIONS BEFORE STARTING INSTALLATION Dynojet Research 2191 Mendenhall Drive North Las Vegas, NV 89081 (800) 992-4993 www.powercommander.com i722-411 2004-2005 Breva 750 - PCIII USB - 1 1 Remove the seat and right hand side cover. 2 Route the harness from the PCIII under the right hand frame tube (Fig. A). 3 Remove the 3 accessible screws that hold the ECU in place (Fig. B). 4 Pull out gently on the ECU to access the stock connector. Unplug this connector from the ECU (Fig. C). Fig. B Fig. A PCIII harness Remove these screws Fig.C Stock Connector i722-411 www.powercommander.com 04-06 Breva 750 - PCIII USB - 2 5 Plug the connectors from the PCIII in-line of the stock wiring harness and ECU (Fig. D). 6 Install the PCIII behind the battery. Use the supplied velcro to keep the unit in place. 7 Locate the stock O2 sensor in the crossover of the stock header. Follow the wires from the O2 sensor to the main wiring harness. 8 Unplug the O2 sensor from the wiring harness and plug the Dynojet O2 Optimizer in-line of the stock wiring harness and O2 sensor (Fig. F). Fig.D PCIII Connectors Stock Connector Fig.E Attach the PCIII with the velcro in this area Fig.F Disconnect O2 sensor i722-411 www.powercommander.com 04-06 Breva 750 - PCIII USB - 3 Install the O2 Optimizer under the left hand side cover (Fig. G). 10 Reinstall the seat and side cover Fig. G 9 www.powercommander.com It is not necessary to alter the values in the highlighted area. i722-411 The O2 optimizer for this model controls the stock closed loop area. This area is represented by the highlighted cells shown. The optimizer is designed to achieve a target AFR of 13.6:1. To use this optimizer you must retain your stock O2 sensor. The Optimizer will blink while the sensors are being heated up. The unit is not functioning properly until the light is solid. 04-06 Breva 750 - PCIII USB - 4
The Epoch Times Inﬁniti EX35 By RUSS HEAPS MyCarData Scoring high on the fun-to-drive meter, the Inﬁniti EX35 crossover is as much a “driver’s vehicle” as it is a utility vehicle. Exhibiting the sporty driving characteristics that we have come to expect from an Inﬁniti, the EX35 provides just enough cargocarrying capability to legitimatize its utility credentials. Easy on the eye, its styling sets it apart from competitors without being polarizing. Although its interior might not be as roomy as some others in the segment, it is well constructed and richly appointed. In other words, the EX35 is well qualiﬁed to hang with the high-end crossover crowd. Sharing a platform and some mechanicals with the G37 creates an expectation of gutsy acceleration and athletic handling. The EX35 doesn’t disappoint. This, despite the fact that its engine and transmission are actually carryovers from the old G35 rather than borrowed from the current G37. Whether it’s the $34,665 entry-level base EX35 or the top- of-the-line $38,265 Journey AWD, every EX35 derives its giddy-up from the same 297-horsepower 3.5-liter V6. A ﬁve-speed, driver-shiftable automatic transmission shuttles engine production to the wheels. This V6/tranny duo musters sufﬁcient power to reach 60 miles per hour from a standstill in less than seven seconds. Both Base and Journey trim levels have standard RWD. For a $1,400 premium, either can be upgraded to AWD. The number of drive wheels makes a slight diﬀerence in fuel economy. The EPA estimates 17 mpg in the city and 24 mpg on
INFINITI OF CINCINNATI www.infinitiofcincinnati.com or email: sales@ infinitiofcincinnati.com. Pete Lobert, General Manager • Dan Tarmey, Sales Manager. “ASK YOUR NEIGHBOR...THEY BOUGHT FROM US!” 2010 INFINITI EX35 AWD CROSSOVER NOW IS THE TIME TO BUY OUR REMAINING 2010’S MSRP $40,970 MODEL #81410 MSRP FACTORY INCENTIVES DEALER DISCOUNT $ $40,970 -$4000 -$2975 SALE PRICE 33,995 $33,995 PLUS TAX, TITLE & DOC. FEE. FINAL SALE PRICE DOESN’T APPLY TO IFS LEASES OR IFS SPECIAL APR’S. SALE ENDS 11-1-2010. INFINITI OF CINCINNATI 513.583.1200 9857 Kings Automall Rd, Cincinnati, OH www.infinitiofcincinnati.com or email: email@example.com Pete Lobert, General Manager • Dan Tarmey, Sales Manager Ask for Pete Lobert for personal assistance • A proud member of the Joseph Auto Group “ASK YOUR NEIGHBOR...THEY BOUGHT FROM US!” 2010 INFINITI EX35 AWD CROSSOVER NOW IS THE TIME TO BUY OUR REMAINING 2010’S MSRP $40,970 MODEL #81410 MSRP FACTORY INCENTIVES DEALER DISCOUNT $ $40,970 -$4000 -$2975 SALE PRICE 33,995 $33,995 PLUS TAX, TITLE & DOC. FEE. FINAL SALE PRICE DOESN’T APPLY TO IFS LEASES OR IFS SPECIAL APR’S. SALE ENDS 11-1-2010. INFINITI OF CINCINNATI 513.583.1200 9857 Kings Automall Rd, Cincinnati, OH www.infinitiofcincinnati.com or email: firstname.lastname@example.org Pete Lobert, General Manager • Dan Tarmey, Sales Manager Ask for Pete Lobert for personal assistance • A proud member of the Joseph Auto Group “ASK YOUR NEIGHBOR...THEY BOUGHT FROM US!” 2010 INFINITI EX35 AWD CROSSOVER NOW IS THE TIME TO BUY OUR REMAINING 2010’S MSRP $40,970 MODEL #81410 MSRP FACTORY INCENTIVES DEALER DISCOUNT $ $40,970 -$4000 -$2975 SALE PRICE 33,995 $33,995 PLUS TAX, TITLE & DOC. FEE. FINAL SALE PRICE DOESN’T APPLY TO IFS LEASES OR IFS SPECIAL APR’S. SALE ENDS 11-1-2010. INFINITI OF CINCINNATI 513.583.1200 9857 Kings Automall Rd, Cincinnati, OH www.infinitiofcincinnati.com or email: email@example.com Pete Lobert, General Manager • Dan Tarmey, Sales Manager Ask for Pete Lobert for personal assistance • A proud member of the Joseph Auto Group
GENI WiMax @ GEC11 Coverage Measurements Caleb Phillips firstname.lastname@example.org Dirk Grunwald email@example.com Measurement Platform Anritsu 2.4-2.5 GHz Antenna (5 dBi) GPS Antenna 2 RP-TNC M to RP-TNC M adapter NM to RP-TNC M adapter Bicycle “Cart-o-Science” Measurement Rig 5' LMR-200 Coaxial Cable Total cable loss ~ 1 dB Anritsu MS2721B Spectrum Analyzer Cat 5e Crossover Cable GPS Antenna 1 Intel 6250 WiMAX MiniPCI-Express Garmin GPS60 Control Computer (Samsung Netbook) 100m Lagged Equilateral Triangle Grid Sample Preliminary Mapping Results Kriging-Interpolated Coverage Map using Effective SNR @ 6Mbps Including measurements and “pop through” 3D building models Multiple Metrics Mapped: - ESNR - CINR - EVM - RCE - Spectral Flatness Error Vector Magnitude Map (for instance) Interpolation technique (Universal Kriging) Produces plot of map's Residual uncertainty... Residual Map Uncertainty (Kriging Variance) For Effective SNR Map
The Honda CR-V hasn’t done it. The Ford Escape, Toyota RAV4 and Hyundai Tucson also have been unable to boost sales this year over last year’s levels. But the Subaru Forester crossover sport utility vehicle, which debuted months ago as an early 2010 model, is setting sales records. In fact, Forester sales in the United States are up 32 percent over 2008 levels to more than 43,000 this year through July. The reason for its appeal? The Forester is a practical, rational purchase in a time of economic uncertainty. Shoppers who want value find the five-door, five-passenger SUV is right-sized — not too big and not too small. With only four-cylinder engines available — with 170to 224-horsepower — it gets decent fuel mileage of at least 19 miles per gallon in city driving. It has the lowest starting retail price — $20,990 with standard all-wheel drive — of any mainstream crossover SUV equipped with all-wheel drive. It earned five out of five stars in government frontal and side crash testing, and the Forester is a recommended buy of Consumer Reports magazine. Factor in that the Forester, which was overhauled as a third-generation model for 2009 and given its arguably best styling ever, offers a nice mix of amenities, and you can see why this people- and cargo-carrying SUV is getting a lot of attention. The $20,990 price is for a base model with manual transmission. The lowest-priced 2010 Forester with automatic is $22,190. Today’s Forester is larger...