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Stem cell therapy in a caprine model of osteoarthritis - Wiley Online ...

Stem Cell Therapy in a Caprine Model of Osteoarthritis J. Mary Murphy,1 David J. Fink,1 Ernst B. Hunziker,2 and Frank P. Barry1 Objective. To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). Methods. Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA was induced unilaterally in the knee joint of donor animals by complete excision of the medial meniscus and resection of the anterior cruciate ligament. After 6 weeks, a single dose of 10 million autologous cells suspended in a dilute solution of sodium hyaluronan was delivered to the injured knee by direct intraarticular injection. Control animals received sodium hyaluronan alone. Results. In cell-treated joints, there was evidence of marked regeneration of the medial meniscus, and implanted cells were detected in the newly formed tissue. Degeneration of the articular cartilage, osteophytic remodeling, and subchondral sclerosis were reduced in cell-treated joints compared with joints treated with vehicle alone without cells. There was no evidence of repair of the ligament in any of the joints. Conclusion. Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA.

Metro-North Railroad - MTA
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Safety & Security Department President J. Giulietti Chief Safety & Security Officer A.E. Kirsch Safety • District Safety & Security Officers • Industrial Hygiene • Safety Data Analysis • Hazard Analysis Emergency Management Security • Security Command Center (SCC) • Security Systems, Projects, & Technology • Pass Office • Emergency Planning • Fire Protection • Fire Command • Fire Brigades Incident Investigation • Accident Investigation and Reporting • Corrective Actions 2 MTA Metro-North Railroad Priority One Safety Program • Program Goals • Defined Roles & Responsibilities • Injury Reduction Targets • Senior Safety Working Group • Priority One Steering Team Objectives • Corporate Commitment o Safety Statement o 12 Essentials Elements • Line Managers • System Safety Program Plan • District Safety Working Group • General Safety Instructions • Local Safety Working Group • Corporate Health/Safety Policies • 24/7 Safety • Auditing • • • • • Training Efficiency Testing Job Safety Analysis Job Safety Briefings Safety Contacts • Recognition • Communication • Accountability • Metrics and Reporting • Safety Reviews • Incident Investigation • Compliance Programs • Department & Local Programs • Post-incident Management • Office Safety Training MTA Metro-North Railroad 3 Objectives 4 MTA Metro-North Railroad Standards & Policies: Safety Policy & Procedures • General Safety Instructions – Update to be published 1Q 2014 • System Safety Program Plan – Improved 2011 Plan based on FRA and APTA guidelines – Buy-In and acceptance from all departments and labor organizations – Expected 2Q 2014 revision of SSPP • Planned Policy & Procedure Updates for 2014 – Asbestos, Lead, Hearing Conservation, Respiratory Protection, Right to Know, Hearing Conservation, Bloodborne Pathogen Protection, Lock-Out/Tag-Out, Fall Protection, Confined Space 5 MTA Metro-North Railroad

METRO NORTh iNITIATIVE - Mass.Gov
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Initiative Live, Work and Play in these ten communities within Greater Boston: Charlestown, Chelsea, East Boston, Everett, Malden, Medford, Melrose, Revere, Somerville, Winthrop For Massachusetts to double its innovation economy in the next ten years, it must expand where businesses settle and people live, work and play. The Executive Office of Housing and Economic Development and the Metro North communities are working together because Metro North has the potential for smart and dynamic growth. It is within six miles of our financial and innovation clusters. It is connected by the Orange and Blue lines—and soon by the Green and Silver lines. It has great walkable neighborhoods, squares and corners. It has slowly been transforming its economic future for years—revitalizing old industrial sites, welcoming new businesses and immigrants from around the world, and building market rate and mixed-income housing. In November 2013, Chelsea, Malden, Melrose and Revere received MassWorks infrastructure grants. See: http://www.mass.gov/hed/economic/eohed/pro/infrastructure/massworks/. In October, MassDOT announced an $83 million silver line extension connecting South Station and the Seaport District with East Boston and Chelsea, with service expected to begin in late 2015, and the Executive Office of Energy and Environmental Affairs announced a $3 million multi-use path providing pedestrian, bicycle, and greenway connections, as well as access to this new transit. The next step, starting November 2013, is a planning process that will involve the communities, the Metropolitan Area Planning Council (MAPC) and the Commonwealth. The process will identify “priority development” and “priority preservation” areas on a local, regional, and state level. In addition, MAPC will analyze opportunities to invest in infrastructure, and to change zoning and permitting, to advance development and preservation. Meanwhile, the Executive Office of Housing and Economic Development is working to promote new and existing businesses in Metro North that involve innovation, the creative economy (including advertising, architecture, arts or other intellectual property products), and food (restaurants and food suppliers). On October 28, 2013, we held a Blue and Orange Innovation Event at East Boston’s Small Business Incubator space. Below are a few examples of what we learned during Secretary Bialecki’s in-depth Metro North tour this spring and summer:...

Accident No.: DCA14MR002 Accident Type: Railroad Train ...

course of the investigation. On December 1, 2013, about 0719 eastern standard time, southbound Metro-North Railroad (Metro-North) passenger train number 8808 derailed at milepost 11.35 on track number 2 of the Metro-North Hudson Line in The Bronx, New York. Train movements on this line are governed by a traffic control system. The train originated in Poughkeepsie, New York with a destination of Grand Central Station in New York City. It consisted of seven passenger cars and one locomotive at the rear pushing the train. As a result of the derailment, 4 passengers died and 59 persons were transported to local hospitals for injuries. Metro-North estimated there were about 115 passengers on the train at the time of the derailment. Damage was estimated by Metro-North to be in excess of $9 million. The weather at the time of the accident was reported as 39° F with cloudy skies. Figure: Aerial view of accident scene National Transportation Safety Board (NTSB) investigators have completed the on-scene work in The Bronx. The investigation will continue at the NTSB headquarters in Washington, D.C. Preliminary results of the investigation include: The derailment occurred in a 6 degree left hand curve where speed was limited to 30 mph. Estimated train speed at the time of the derailment was at 82 mph. Detailed inspection and testing of the signal system, train brakes, and other mechanical equipment did not identify any anomalies. An inspection of the track in the derailment area did not identify any pre-accident anomalies. All cars on the train and the locomotive derailed. Between December 1 and 11, 2013, investigators completed interviews of train crews and first responders. Interview transcripts will be included in the public docket upon release. Locomotive event recorders were sent to the NTSB laboratory in Washington, D.C. for further analysis. The parties to the investigation include the Federal Railroad Administration, Metro-North Railroad, New York Public Transportation Safety Board, Teamsters Local 808, New York Police Department, New York Fire Department, and Bombardier Transportation. The Association of Commuter Rail Employees (ACRE) was initially designated as a party. However, because one of ACRE’s senior officials made unauthorized comments on the investigation to the media, ACRE was removed as a party on December 3, 2013.

Things To Keep In Mind Before Hiring Skips In Chichester

Arun Waste Services Ltd is a local family owned and run business. We are fully licensed waste carriers, registered with the Environment Agency and have many years experience in the trade to ensure an expert service"

User manual ACER ASPIRE 5315 - mypdfmanuals.com

You can read the recommendations in the user guide, the technical guide or the installation guide for ACER ASPIRE 5315. You'll find the answers to all your questions on the ACER ASPIRE 5315 in the user manual (information, specifications, safety advice, size, accessories, etc.). Detailed instructions for use are in the User's Guide. User manual ACER ASPIRE 5315 User guide ACER ASPIRE 5315 Operating instructions ACER ASPIRE 5315 Instructions for use ACER ASPIRE 5315 Instruction manual ACER ASPIRE 5315 Your user manual ACER ASPIRE 5315 http://mypdfmanuals.com/dref/1115241 Manual abstract: Never spill liquid of any kind onto or into the product. To avoid damage of internal components and to prevent battery leakage, do not place the product on a vibrating surface. Never use it under sporting, exercising, or any vibrating environment which will probably cause unexpected short current or damage rotor devices, HDD, Optical drive, and even exposure risk from lithium battery pack. · · · Using electrical power · This product should be operated from the type of power indicated on the marking label. If you are not sure of the type of power available, consult your dealer or local power company. Do not allow anything to rest on the power cord. Do not locate this product where people will walk on the cord. If an extension cord is used with this product, make sure that the total ampere rating of the equipment plugged into the extension cord does not exceed the extension cord ampere rating. Also, make sure that the total rating of all products plugged into the wall outlet does not exceed the fuse rating. Do not overload a power outlet, strip or receptacle by plugging in too many devices. The overall system load must not exceed 80% of the branch circuit rating. If power strips are used, the load should not exceed 80% of the power strip's input rating. This product's AC adapter is equipped with a three-wire grounded plug. The plug only fits in a grounded power outlet. Make sure the power outlet is properly grounded before inserting the AC adapter plug. Do not insert the plug into a non-grounded power outlet. Contact your electrician for details. · · · · Warning! The grounding pin is a safety feature. Using a power outlet that is not properly grounded may result in electric shock and/or injury.

Fan on Acer Aspire 5315 not working - Rqgg

Asked by Desiree on 2012-06-12T13:20:05-04:00 I have recently installed Ubuntu 12.04 on my old laptop (Acer Aspire 5315 ) and observed that fan is not working properly on Ubuntu. How could I solve this problem? Best Answer Answer by Jasmines on 2012-06-12T13:37:29-04:00 This is a well known design problem with the Acer Aspire 5315 preventing the fan to work properly and eventually shutting down the computer to protect from overheating. Solution comes from http://ubuntuforums.org/showpost.php?p=4651436&postcount=99 and http://www.mail-archive.com/acpi-bugzilla@lists.sourceforge.net/msg14582.html. You will have to register an account in order to download the fix. You'll have to install mempat binary and acer_fancontrol script into /usr/bin. You have to find out the correct memory address for mmap(). For the 5315 wit 1.5G RAM PATCH_ADDRESS=x5F6BCEAF. Add acer_fancontrol to /etc/rc.local and restart. Source: http://www.fugaz.net/2010/01/23/acer-aspire-fan-issue-solved/ In other cases, a simple bios upgrade worked: http://support.acer-euro.com/drivers/notebook/as_5315.html Archives Technology Ubuntu Jun 12th, 2012 Week 24, 2012 June, 2012 All Answers Answer by Kaltej on 2012-11-28T16:40:57-05:00 Issue: What the problem is that its a problem with the version of Bios your using,its a bug which prevents your CPU fan from working and causes your PC to overheat so then your Motherboard shuts the PC down to prevent damage. Solution: The solution is to download the latest Bios Version for your Acer Aspire 5315, theirs only a windows installer for this on the Acer website,Link for Windows Bios Update:http://support.acer.com/us/en/product/default.aspx?tab=1&modelId=50.

2013-2014 scholarship application packet content - 100 Black Men ...

2013-2014 SCHOLARSHIP APPLICATION PACKET CONTENT 1. Scholarship Application 100 Black Men of America’s Future Leader Scholarship Application will be available after November 5th and may be acquired from a local chapter, our World Headquarters or our web site www.100blackmen.org. It is encouraged and preferred that the applications be typed. 2. Essay Applicants are required to submit a 600 word, double-spaced essay using one of the following topics. It is also encouraged and preferred that the essays be typed. 1. Obesity: The link between obesity and health issues such as diabetes and hypertension is powerful. What strategies should schools and communities employ to reduce obesity among young people? Be detailed in your response. 2. Higher Education: Higher education has always been stressed in order to obtain a good job and a higher salary. Today one out of every two college graduates are unable to find a job and those who are employed are often underpaid. Based upon these facts "Is earning a college degree relevant in today's society"? Be detailed in your response. 3. Gang Violence: Gang violence in America continues to be a problem in many communities. What are the major causes of gang violence? Now provide a series of strategies that you would recommend eradicating gang violence in America. Be detailed in your response. 4. Hazing: Hazing has become a major problem in high schools and on college and university campuses. What is the history and purpose of hazing and why do institutions and organizations tolerate and foster this abusive behavior? Would you participate in a hazing activity to become a member of a group or fraternity or sorority? Be detailed in your response.

2013-2014 Scholarships & Grants - ROE #11

Scholarships & Grants This publication is not intended to be a complete listing of all scholarships and grants which are available. As the Regional Office of Education receives information on scholarships, we will update this listing. Students are urged to check with their high school counselor or the office of financial aid at the university or college they wish to attend. Many departments have special scholarships for students in that field of study and most schools have merit scholarships for academic achievement. To order free financial aid material, please contact the U.S. Department of Education. 2 Abbott and Fenner Scholarship: Abbott and Fenner Business Consultants Scholarship-Students are required to submit an essay on the topic that appears on the page attached to this link: http://www.abbottandfenner.com/scholarships.htm . Application: Available online at http://www.abbottandfenner.com/scholarships.htm . Application Deadline: June 14, 2014. Aldrich Green Scholarship: (Cumberland students ONLY) The Aldrich Green scholarship is offered to Cumberland high school seniors who aspire to continue their education at the college level. The award can be up to $1,000 and will be given to a student annually but will be distributed $500 per semester for the time he or she is enrolled in college. Special consideration will be given to students planning to return to Cumberland county to reside in and/or seek employment. Eligibility Requirements: The applicant must (1) have good academic standings, (2) have some school involvement (work experience may be considered) and (3) have goodcitizenship/behavior. Application: Is available online at www.firstneighbor.com/scholarship/scholarships.htm or contacting your local First Neighbor Bank. Application deadline: April 30, 2014. American Legion Auxiliary: Children of Warriors National Presidents’ Scholarship: This scholarship provides funds to assist children of those who have served. This award will be presented to 15 students annually who excel in academics and volunteer in their communities. Eligibility Requirements: The applicant must study only at a 4-year accredited college or university and may be used for tuition, books, fees, room and board. Candidates shall be daughters, stepdaughters, sons, stepsons, grandsons, step-grandsons, granddaughters, step-granddaughters, great-granddaughters, step-great granddaughters, great-grandsons, step-great grandsons of veterans who served in the...

President Bachelet Chile; President Mujica Uruguay(Nobel Nominee); Mayor Brown Compton, CA; Carlos González Gutiérrez, Consul General Mexico Honored @ Women of Color Day

Women of Color Day/Diversity Event to Honor Local Sacramento/Northern California Women and Men, noted State and International leaders and Celebrate Communities in Americas. Event also Launches WomenWorldCulture, New Global Network.

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