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When a ﬂow is driven through a deformable channel or tube, interactions between ﬂuid-mechanical and elastic forces can lead to a variety of biologically signiﬁcant phenomena, including nonlinear pressure-drop/ﬂow-rate relations, wave propagation, and the generation of instabilities. Understanding the physical origin and nature of these phenomena remains a signiﬁcant experimental, analytical, and computational challenge, involving unsteady ﬂows at low or high Reynolds numbers, large-amplitude ﬂuid-structure interactions, free-surface ﬂows, and intrinsically 2D or 3D motion. Whereas frequently the internal ﬂow involves a single ﬂuid phase (albeit often of a complex biological ﬂuid such as blood), in many instances the presence of two or more distinct ﬂowing phases is of primary importance (as is the case for air-liquid ﬂows in peripheral lung airways, for example). We divide this review accordingly: Section 2 treats single-phase ﬂows in collapsible tubes, Section 3 covers recent applications of such ﬂows to a wide range of physiological 0066-4189/04/0115-0121$14.00
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