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Suzuki Forenza transmission control system

Stem Cell Therapy: the ethical issues - Nuffield Council on Bioethics

Stem Cell Therapy: the ethical issues a discussion paper Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3EG Telephone: Fax: Email: Website: 020 7681 9619 020 7637 1712 bioethics@nuffieldfoundation.org http://www.nuffieldfoundation.org/bioethics April 2000 © Nuffield Council on Bioethics 2000 All rights reserved. Apart from fair dealing for the purpose of private study, research, criticism or review, no part of the publication may be produced, stored in a retrieval system or transmitted in any form, or by any means, without prior permission of the copyright owners. Nuffield Council on Bioethics Professor Ian Kennedy (Chairman) Professor Martin Bobrow CBE (Deputy Chairman) Professor Tom Baldwin Professor Sir Kenneth Calman KCB FRSE* Reverend Professor Duncan Forrester DD Professor Brian Heap CBE FRS Mrs Rebecca Howard Lady Hornby Professor John Ledingham Mr Derek Osborn CB Professor Catherine Peckham CBE Professor Martin Raff FRS Mr Nick Ross Professor Herbert Sewell Professor Albert Weale FBA * (co-opted member of Council for the period of his Chairmanship of the Working Party on the ethics of healthcare-related research in developing countries) The terms of reference are as follows: 1 to identify and define ethical questions raised by recent advances in biological and medical research in order to respond to, and to anticipate, public concern; 2 to make arrangements for examining and reporting on such questions with a view to promoting public understanding and discussion; this may lead, where needed, to the formulation of new guidelines by the appropriate regulatory or other body; 3 in the light of the outcome of its work, to publish reports; and to make representations, as the Council may judge appropriate. The Nuffield Council on Bioethics is funded jointly by the Medical Research Council, the Nuffield Foundation and the Wellcome Trust Attendees of the Round Table meeting on Stem Cell Therapy: the ethical issues Professor Martin Bobrow CBE, Department of Medical Genetics, Cambridge Institute for Medical Research and Deputy Chairman of Nuffield Council on Bioethics Professor Tom Baldwin, Department of Philosophy, University of York, member of Nuffield Council on Bioethics Lady Hornby, Chairman of The Kingwood Trust, member of Nuffield Council on Bioethics...

Stem Cell Treatments For Cerebral Palsy Factsheet For - UCLA ...

STEM CELLS AND CEREBRAL PALSY Cerebral palsy (CP) is an umbrella term which includes several forms and levels of nonprogressive brain-related injury, which cause limitations in muscle control, movement and mobility (known as neuromotor impairment) and other symptoms that lead to physical disability. CP is caused by many factors, and can include infection before birth, premature birth and lack of oxygen around the time of birth. It is thought that the major common feature in CP is a lack of blood and oxygen to the brain during fetal development and/or delivery, known as a hypoxic-ischemic insult. The cells most vulnerable to this hypoxic-ischemic insult are oligodendrocytes, the support cells that wrap nerve cells (or neurons) with a protective white fat called myelin, hence the term white matter of the brain. Because of this myelin, neurons can send electrical signals efficiently throughout the body. Once oligodendrocytes die, the neurons are no longer protected and they eventually die. If myelin could be replaced before neurons die, neurons could be spared and motor impairments could be lessened. For this reason, scientists are investigating whether lost oligodendrocytes can be replaced with stem cells. Stem cells are unspecialized cells which can become specialized cells such as brain cells, heart cells or muscle cells. The process of developing into a specialized cell is known as differentiation. Stem cells can also multiply over and over again, a process known as proliferation. During the process of proliferation the stem cell either remains unspecialized or, under the right condition, can become a specialized cell such as a brain cell. Replacing neurons themselves would be like trying to rewire a giant switchboard with tens of thousands of ports but no labels, where improper connections could lead to pain. It is for this reason that the aim of many cell transplantation strategies now being tested is to replace lost oligodendrocytes rather than to make and successfully connect new neurons. Recent decades have seen advances in our knowledge of how to study and use stem cells. It is expected we will develop ways to transplant stem cells into damaged tissues to treat and cure injury and diseases like CP. From Mice to Humans...

Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem ...

Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem Cell Study for the Treatment of Diabetic Foot Ulcers Grafix closes three times as many wounds as standard of care - the largest relative improvement ever reported in a multi-center, randomized, controlled clinical trial for DFU COLUMBIA, Md. - August 13,2013 - Osiris Therapeutics, Inc. (NASDAQ: OSIR), reported today that its multicenter, randomized, controlled clinical trial comparing the safety and effectiveness of Grafix® to standard of care in patients with chronic diabetic foot ulcers had met the pre-specified stopping rules for overwhelming efficacy as determined by the data monitoring committee during a planned interim analysis. For the primary endpoint, 62% of patients receiving Grafix had complete wound closure compared to only 21% (p<0.0001) of patients who received conventional treatment for their wounds - a relative improvement of 191% and the largest ever reported from such a study. A total of 131 patients were enrolled with the interim analysis being conducted on the first 97 to complete the trial. The trial also reached statistical significance in favor of Grafix on all top-line secondary endpoints, demonstrating faster wound closure and a reduction in the number of treatments needed to achieve wound closure. In the crossover phase of the trial, patients whose wounds failed to close after 12 weeks of standard of care had an 80% closure rate when switched to Grafix. Importantly, patients randomized to receive standard of care were 74% more likely to experience an adverse event than those receiving Grafix (p=0.008). As a result, the blinded phase of the trial is being discontinued immediately and all patients randomized to the control arm will be offered treatment with Grafix. “Today, Osiris has established a new standard in diabetic wound care and has demonstrated to the world the tremendous impact stem cell products can have in medicine,” said C. Randal Mills, Ph.D., Chief Executive Officer. “Diabetic foot ulcers afflict 25% of all diabetics and are responsible for more hospitalizations than any other diabetic complication. With 25 million diabetics in the United States, the cost to our health care system is enormous. Through this rigorous study we have shown that Grafix can heal more patients, in less time, and with fewer complications.”

Stem cell therapy in a caprine model of osteoarthritis - Wiley Online ...

Stem Cell Therapy in a Caprine Model of Osteoarthritis J. Mary Murphy,1 David J. Fink,1 Ernst B. Hunziker,2 and Frank P. Barry1 Objective. To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). Methods. Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA was induced unilaterally in the knee joint of donor animals by complete excision of the medial meniscus and resection of the anterior cruciate ligament. After 6 weeks, a single dose of 10 million autologous cells suspended in a dilute solution of sodium hyaluronan was delivered to the injured knee by direct intraarticular injection. Control animals received sodium hyaluronan alone. Results. In cell-treated joints, there was evidence of marked regeneration of the medial meniscus, and implanted cells were detected in the newly formed tissue. Degeneration of the articular cartilage, osteophytic remodeling, and subchondral sclerosis were reduced in cell-treated joints compared with joints treated with vehicle alone without cells. There was no evidence of repair of the ligament in any of the joints. Conclusion. Local delivery of adult mesenchymal stem cells to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction normally seen in this model of OA.

2013 Brochure - Carolina Computing Initiative

Why Should I Purchase a CCI Laptop? You’ll want to purchase one of the official CCI Laptops because the laptop packages available to you as an entering UNC-Chapel Hill student are the best value anywhere. Our comprehensive program of hardware, software, and support ensures an unparalleled student computing experience. Only with the purchase of a CCI Laptop will you be eligible for all the programs and services below: • A 4-year Comprehensive Protection Plan including: 4 Years of Manufacturer’s Warranty Coverage 4 Years of Accidental Damage Coverage 4 Years of Laptop Insurance Coverage • Computer Support 24 x 7 • An Award-winning On-campus Repair Center with a pool of loaner laptops • An Extensive Software Package • Security Solutions for keeping your computer and data secured When should I place my order? 8 out of 10 Carolina undergraduates choose a CCI Laptop package to fulfill the laptop requirement. CCI Laptop packages can be ordered through the CCI Website starting in early April. Submit your order by May 15 and your laptop will be waiting for you at your New Student Orientation session this summer. Students admitted after May 15 should order as soon as possible and at least 2 weeks before your New Student Orientation. How do I order my CCI Laptop? [1] Decide which CCI Laptop model you want to purchase [2] Choose Your Printer [3] Choose Your Accessories They will get more than award-winning laptops. They will get support, service, [4] Place Your Order through the CCI website or Call 919-962-8534 Monday-Friday 10am-5pm and software ensuring them an unparalleled student computing experience. How do I pay for my CCI Laptop? [1] Credit Card (Visa, Mastercard or American Express) [2] Laptop grant from the University What if I don’t buy a CCI Laptop? Please note that, while students are not required to purchase a CCI Laptop, students are required to have a laptop that meets the minimum requirements specified. Software and operating system support for non-CCI laptops is on a best-effort basis. Hardware support for non-CCI laptops is the responsibility of the owner. Loaner laptops are only available to students who purchase a CCI Laptop through UNC Student Stores. If you have any additional questions please visit our FAQ...

HIGH-END NOTEBOOK PERFORMANCE COMPARISON: DELL PRECISION M3800 VS. 2012 AND 2013 APPLE MACBOOK PRO WITH RETINA DISPLAY

When selecting a high-end portable workstation for multimedia creation and viewing, performance counts. Large files and complex applications can slow systems with limited amounts of RAM or basic graphic cards. Those who invest in a system with a powerful 4th generation Intel® Core™ i7 processor, 16 GB of RAM, and two heavy-duty graphics cards do so because their compute-intensive workloads require such hardware. In our labs, we tested three current high-end portable systems, a 4th generation Intel Core processor-based Dell Precision M3800 with QHD+ touchscreen display, a similarly configured 2013 Apple MacBook Pro with Retina display, and a 2012 Apple MacBook Pro with Retina display, to see how well they performed. While the systems were comparably configured, the Dell Precision M3800 has a touch screen and runs Windows 8.1, allowing users to select, zoom, and edit their work right on the screen. It also has three times the storage capacity of the 2012 MacBook Pro and 33 percent more than the 2013 MacBook Pro, which is very useful for storing large multimedia files. The Dell Precision M3800 outperformed both MacBook Pro systems on several tests. Along with its $2,249 purchase price, which is 13.5 percent lower than that of the 2013 MacBook Pro, these advantages make the Dell Precision M3800 an excellent choice for those who work with multimedia content and need an extremely powerful system they can use at the office and on the go.

Metro-North Railroad - MTA
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Safety & Security Department President J. Giulietti Chief Safety & Security Officer A.E. Kirsch Safety • District Safety & Security Officers • Industrial Hygiene • Safety Data Analysis • Hazard Analysis Emergency Management Security • Security Command Center (SCC) • Security Systems, Projects, & Technology • Pass Office • Emergency Planning • Fire Protection • Fire Command • Fire Brigades Incident Investigation • Accident Investigation and Reporting • Corrective Actions 2 MTA Metro-North Railroad Priority One Safety Program • Program Goals • Defined Roles & Responsibilities • Injury Reduction Targets • Senior Safety Working Group • Priority One Steering Team Objectives • Corporate Commitment o Safety Statement o 12 Essentials Elements • Line Managers • System Safety Program Plan • District Safety Working Group • General Safety Instructions • Local Safety Working Group • Corporate Health/Safety Policies • 24/7 Safety • Auditing • • • • • Training Efficiency Testing Job Safety Analysis Job Safety Briefings Safety Contacts • Recognition • Communication • Accountability • Metrics and Reporting • Safety Reviews • Incident Investigation • Compliance Programs • Department & Local Programs • Post-incident Management • Office Safety Training MTA Metro-North Railroad 3 Objectives 4 MTA Metro-North Railroad Standards & Policies: Safety Policy & Procedures • General Safety Instructions – Update to be published 1Q 2014 • System Safety Program Plan – Improved 2011 Plan based on FRA and APTA guidelines – Buy-In and acceptance from all departments and labor organizations – Expected 2Q 2014 revision of SSPP • Planned Policy & Procedure Updates for 2014 – Asbestos, Lead, Hearing Conservation, Respiratory Protection, Right to Know, Hearing Conservation, Bloodborne Pathogen Protection, Lock-Out/Tag-Out, Fall Protection, Confined Space 5 MTA Metro-North Railroad

Metro North Regional Employment Board Strategic Plan FY 2013 ...

In the context of today’s changing fiscal landscape on both the state and federal level, the Metro North REB is entering a stage of development that is guided by new opportunities as well as challenges. As it moves forward, the REB must identify creative new approaches, consider diverse sources of funding, and streamline existing systems to optimize efficiency. In addition, undertaking a renewed philosophy of continuous improvement and innovation in program implementation will be crucial to adjusting approaches in workforce development to align with the ever-changing economy. Historically, the education and workforce development systems have been only sporadically, marginally, or indirectly connected to business needs. Although some components of the workforce development system (notably community-based training and employment programs), have a long history of aligning their training with strong employer partnerships, the K-12 and college education systems have been grounded in a philosophy of preparing people for life, by providing a broad, general education, and only targeting training to specific occupations later in the post-secondary experience. In addition, education and workforce development have struggled to keep up with changing technologies and trends in industry, often lacking critical information about where career opportunities exist and what skills and abilities are necessary to take advantage of those options. As a result, education and training are often disconnected from real-time employer needs, and as a result, unemployed youth and adults often lack the necessary skills to enter those jobs that do exist, creating a growing class of disconnected or never connected workers.

FINAL Deep Dive Report (S10-140310-003)[1] - Federal Railroad ...

On May 17, 2013, in Bridgeport, Connecticut, an accident occurred on Metro-North’s New Haven Line, when an eastbound Metro-North train of 8 cars, traveling 74 mph, derailed and came to rest on an adjacent track. Approximately 20 seconds later, a westbound Metro-North train on that adjacent track struck the derailed train. As a result of the accident, more than 50 people, some seriously injured, were hospitalized, rail operations were suspended, and millions in property damage occurred. • On May 28, 2013, a second accident occurred when a Metro-North train in West Haven, Connecticut, that was traveling 70 mph, struck and killed a Metro-North maintenance-ofway (MOW) employee who was part of a roadway work group performing railroad maintenance on a construction project. • On July 18, 2013, a third accident occurred when a CSX Transportation freight train derailed while traveling over Metro-North’s system. No one was injured, but property damage was significant. • On December 1, 2013, the fourth accident occurred when a Metro-North train of 7 cars traveling south from Poughkeepsie, New York, to Grand Central Terminal in New York City, derailed as it approached the Spuyten Duyvil Station. All cars derailed and the front cab came to rest close to the Harlem River. Four passengers were killed, and more than 70 were injured. Rail operations were suspended, and millions of dollars in property damage alone was sustained. On December 3, 2013, 2 days after the fourth and most serious of these accidents, FRA sent a letter to MTA expressing support for Governor Andrew Cuomo’s directive that MTA hold a safety stand-down, and directing Metro-North to implement a Confidential Close Call Reporting System (C3RS) (Appendix 2). Additionally, FRA issued Emergency Order 29 and Safety Advisory 2013-08. • Emergency Order 29, issued on December 6, 2013, required Metro-North to take immediate action to prevent excessive train speeds by identifying and prioritizing highrisk areas, modifying its existing signal system to ensure speed limits are obeyed, and 1 requiring a higher level of engagement and communication among operating crewmembers in areas in which major speed restrictions are in place. • Safety Advisory 2013-08, issued on December 10, 2013, urged railroads to provide additional training, increase the frequency of operational testing, and reinforced the importance of communication between crew members. The purpose was to ensure that all railroads adhere to Federal regulations and railroad operating rules regarding maximum authorized train speed limits. On December 16, 2013, FRA launched Operation Deep Dive, an assessment of Metro-North’s operations and safety compliance. More than 60 technical and human factor experts comprising 14 teams, conducted a 60-day comprehensive safety assessment of Metro-North. With assistance from the Federal Transit Administration, these experts reviewed and assessed Metro-North’s safety-related processes and procedures, its compliance with safety regulations and requirements, and its overall safety culture. In assessing Metro-North, the Deep Dive team evaluated:...

Accident No.: DCA14MR002 Accident Type: Railroad Train ...

course of the investigation. On December 1, 2013, about 0719 eastern standard time, southbound Metro-North Railroad (Metro-North) passenger train number 8808 derailed at milepost 11.35 on track number 2 of the Metro-North Hudson Line in The Bronx, New York. Train movements on this line are governed by a traffic control system. The train originated in Poughkeepsie, New York with a destination of Grand Central Station in New York City. It consisted of seven passenger cars and one locomotive at the rear pushing the train. As a result of the derailment, 4 passengers died and 59 persons were transported to local hospitals for injuries. Metro-North estimated there were about 115 passengers on the train at the time of the derailment. Damage was estimated by Metro-North to be in excess of $9 million. The weather at the time of the accident was reported as 39° F with cloudy skies. Figure: Aerial view of accident scene National Transportation Safety Board (NTSB) investigators have completed the on-scene work in The Bronx. The investigation will continue at the NTSB headquarters in Washington, D.C. Preliminary results of the investigation include: The derailment occurred in a 6 degree left hand curve where speed was limited to 30 mph. Estimated train speed at the time of the derailment was at 82 mph. Detailed inspection and testing of the signal system, train brakes, and other mechanical equipment did not identify any anomalies. An inspection of the track in the derailment area did not identify any pre-accident anomalies. All cars on the train and the locomotive derailed. Between December 1 and 11, 2013, investigators completed interviews of train crews and first responders. Interview transcripts will be included in the public docket upon release. Locomotive event recorders were sent to the NTSB laboratory in Washington, D.C. for further analysis. The parties to the investigation include the Federal Railroad Administration, Metro-North Railroad, New York Public Transportation Safety Board, Teamsters Local 808, New York Police Department, New York Fire Department, and Bombardier Transportation. The Association of Commuter Rail Employees (ACRE) was initially designated as a party. However, because one of ACRE’s senior officials made unauthorized comments on the investigation to the media, ACRE was removed as a party on December 3, 2013.

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