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Overview of FDA Perspective on the Ethics of Stem Cell Therapy Robert M. Nelson, M.D., Ph.D. Pediatric Ethicist, Office of Pediatric Therapeutics Office of the Commissioner, Food and Drug Administration Robert.Nelson@fda.hhs.gov Presented on April 4, 2010 Disclosure • The views expressed in this presentation are those of the speaker and do not necessarily represent the policy of either the Food and Drug Administration or the Department of Health and Human Services. • The speaker has no financial interests to disclose with respect to the contents of this presentation. 2 Topics • Origin and Clinical Uses of Stem Cells (SC) • Ethical Issues in SC Research – NIH Criteria for hESC Registration – Evolving Debate over hESC/iPSC • ISSCR Guidelines for SC Clinical Trials • Ethics of FDA-Regulated Clinical Trials 3 Origin of Stem Cells Cells are described as pluripotent if they can form all the cell types of the adult organism. If, in addition, they can form the extraembryonic tissues of the embryo, they are described as totipotent. Watt and Driskell Philos Trans R Soc Lond B Biol Sci 2010;365:155-163. 4 Origin of Stem Cells Multipotent stem cells can form all the differentiated cell types of a given tissue. In some cases, a tissue contains only one differentiated lineage and the stem cells that maintain that lineage are described as unipotent. Watt and Driskell Philos Trans R Soc Lond B Biol Sci 2010;365:155-163.
Program Description The Florida Bright Futures Scholarship Program establishes three lottery-funded scholarships to reward Florida high school graduates for high academic achievement. The Florida Bright Futures Scholarship Program is comprised of the following three awards: • Florida Academic Scholars (FAS) award including Academic Top Scholars (ATS) award • Florida Medallion Scholars (FMS) award • Florida Gold Seal Vocational Scholars (GSV) award financial aid office or admissions office of the institution the student plans to attend. • Not owe a repayment or be in default under any state or federal grant, loan, or scholarship program unless satisfactory arrangements to repay have been made. • Receive if awarded, as an Academic Top Scholar (ATS), an additional cost per credit hour award established by the Florida Legislature in the General Appropriations Act in addition to the Florida Academic Scholars award. The ATS awardee is announced by the Florida Department of Education before the end of the fall term after all term one disbursements are reported. The ATS is awarded to the Florida Academic Scholar with the highest academic ranking in each county (based on the product of multiplying the Bright Futures GPA and the highest qualifying SAT/ACT test score). For current year award amounts visit - www.FloridaStudentFinancialAid.org/SSFAD/bf/awardamt.htm. • NEW - Submission of a Free Application for Federal Student Aid (FAFSA) is NO LONGER required; however, students are encouraged to submit the FAFSA to learn of potential eligibility for additional state and federal aid. Visit the website at www. fafsa.ed.gov for online processing. Applying for an Award For Initial Eligibility the student will: • Submit a fully completed error free Initial Student Florida Financial Aid Application during the last year in high school (after December 1 and prior to graduation) available online at www.FloridaStudentFinancialAid.org (select State Grants, Scholarships & Applications, then Apply Here). The application gives the Florida Department of Education (FDOE) permission to evaluate the student’s high school transcript and standardized test scores for eligibility for a Bright Futures Scholarship and other state scholarships and grants. • Apply during the last year in high school, before graduation, or forfeit all future eligibility for a Bright Futures Scholarship. ...
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Why a 4°C Warmer World Must be Avoided Turn Down the Heat Why a 4°C Warmer World Must be Avoided November 2012 A Report for the World Bank by the Potsdam Institute for Climate Impact Research and Climate Analytics © 2012 International Bank for Reconstruction and Development / The World Bank 1818 H Street NW Washington DC 20433 Telephone: 202-473-1000 Internet: www.worldbank.org This work is a product of the staff of The World Bank with external contributions. The findings, interpretations, and conclusions expressed in this work do not necessarily reflect the views of The World Bank, its Board of Executive Directors, or the governments they represent. The World Bank does not guarantee the accuracy of the data included in this work. The boundaries, colors, denominations, and other information shown on any map in this work do not imply any judgment on the part of The World Bank concerning the legal status of any territory or the endorsement or acceptance of such boundaries. Rights and Permissions The material in this work is subject to copyright. Because The World Bank encourages dissemination of its knowledge, this work may be reproduced, in whole or in part, for noncommercial purposes as long as full attribution to this work is given. Any queries on rights and licenses, including subsidiary rights, should be addressed to the Office of the Publisher, The World Bank, 1818 H Street NW, Washington, DC 20433, USA; fax: 202-522-2422; e-mail: firstname.lastname@example.org. Contents Acknowledgements vii Foreword Executive Summary Observed Impacts and Changes to the Climate System Projected Climate Change Impacts in a 4°C World Rising CO2 Concentration and Ocean Acidification Rising Sea Levels, Coastal Inundation and Loss Risks to Human Support Systems: Food, Water, Ecosystems, and Human Health Risks of Disruptions and Displacements in a 4°C World
A project of this size, scope, and duration requires the hard work and commitment of many people. We would especially like to thank C.K. Mertz of Decision Research; Russell Shaddox of Quicksilver Communication; Karen Akerlof and Carol Jeter of the George Mason University Center for Climate Change Communication; Joe Garrett, Bill McCready and Sergei Rodkin of Knowledge Networks; Dan Esty and Melissa Goodall of the Yale Center for Environmental Law and Policy; Andrew Light of the Center for Global Ethics at George Mason University, Gus Speth, Dean of the Yale School of Forestry and Environmental Studies; Lisa Fernandez of the Yale Project on Climate Change; Tim Northrop and Eugenie Gentry of the Yale School of F&ES Development Office; the Center for American Progress; and Bud Ward of the Yale Forum on Climate Change & the Media. Finally, we thank our families for their love and support. We would also like to extend our sincere gratitude to the generous funders who made this research possible: The Yale Center for Environmental Law and Policy; the Betsy and Jesse Fink Foundation; the 11th Hour Project; the Pacific Foundation; and an RWJF Investigator Award in Health Policy Research from the Robert Wood Johnson Foundation. ...
BAHASA INGGRIS : XII IPA/IPS : 90 menit Mata Pelajaran Kelas/ Program Waktu Choose A, B, C, D, or E for the correct answer. Listening Section In this section of the test, you will have the chance to show how well you understand spoken English. There are three parts to this section with special directions for each part. Part I Questions 1 to 5 Directions: In this part of the test, you will hear some dialogues or questions spoken in English. The dialogues or questions will be spoken two times. They will not be printed in your test book so you must listen carefully to understand what the speakers say. After you hear a dialogue and the question about it, read the five possible answers and decide which one would be the best answer to the question you have heard. Now listen to a sample question. You will hear: Man : How about exercising tomorrow morning? Woman : Alright. Pick me up at 6. You will also hear: Narrator : What will the man do? You will read in your test book: a. Do exercise at 6. b. Go with six women. c. Take exercise alone. d. Leave the woman alone. e. come to the woman’s house. The best answer to the question is “Come to the woman’s house.” Therefore, you should choose answer (e). 1. a. She cut herself quite badly. b. She wasn’t given any help. c. She cried while slicing onions. d. She sliced the onions hurriedly. e. She was going to make fried rice. 2. a. Do his assignment b. See a book fair. c. Buy a history book. d. Offer the woman a book. e. Go to the woman’s house. 3. a. To buy a novel. b. To read a novel. c. To lend a novel. d. To go to a bookstore. e. To finish reading a novel. 4. a.1 b.2 c.3 d.4 e.5 Latihan Soal UN dan Ujian SNMPTN /PTS 2012/2013 1 5. a.1 b.2 c.3 d.4 e.5 PART II Questions 6 to 10 Directions: In this part of the test, you will hear a statement or a question spoken in English, foolowed by four responses, also spoken in English. The statement or question and the responses will be spoken two times. They will not be printed in your test book, so you must listen carefully to understand what the speakers say. You have to choose the best response to each statement or question. Now listen to a sample question: You will hear: Woman : Good morning, John. How are you? Man : …… You will also hear: a. I am fine, thank you. c. Let me introduce myself. b. I am in the living room. d. My name is John Travolta. 6. 7. 8. 9. 10. The best answer to the question “How are you?” is choice (a), “I’m fine, thank you.” Therefore, you should choose answer (a). Mark your answer on your answer sheet. Mark your answer on your answer sheet. Mark your answer on your answer sheet. Mark your answer on your answer sheet. Mark your answer on your answer sheet. Part III Questions 11 to 15 Directions: In this part of the test, you will hear several monologues. Each monologue will be spoken two times. They will not be printed in your test book so you must listen carefully to understand what the speakers say. After you hear a monologue and the questions about it, read the five possible answers and decide which one would be the best answer to the questions you have heard. 11. a. b. c. Goose hunting An unfaithful dog An unusual accident d. A mathematics teacher e. Chambers Country Policeman 12. a. b. c. Arthur Houston Labrador d. Perry Price e. Joe LaRive Latihan Soal UN dan Ujian SNMPTN /PTS 2012/2013 2 13. a. b. c. It lies on high land. It is densely populated. It lies on a flat low plain area. d. The climate is hot and humid. e. It is at the mouth of the Ciliwung River. 14. a. b. c. James’ pet dog Muggs’ characteristics Muggs’ strange behavior d. The night when Muggs died e. Browny, the Cocker Spaniel 15. a. b. c. Andre Muggs James d. Browny e. George This is the end of the listening section Reading Section Text 1 is for number 16 Miss Ratu, I’m going to have a business trip to Surabaya and Jakarta. I’d like to go by train from here to Surabaya this afternoon and spend two days there. Then I’d like to fly to Jakarta and stay there for three nights. 1. Please book an executive class train ticket and seat reservation to Surabaya. 2. Please book single room with bath for three nights (Wed 1, Thurs 2, Fri 3) at Sulthan Hotel, Jakarta Selatan. Thanks, Raja 16. What is the message about? A. B. C. D. E. Mr. Raja’s request to his secretary. Ratu’s plan to Surabaya. A business trip to Surabaya. Mr. Raja’s schedule to Jakarta. A reservation for a train ticket. Text 2 is for number 17 Hi, Guys! 78 shs will hold a Fund Raising Activity next month. It is intended to help victims of earthquake in several areas in Aceh. Everyone who is interested in this activity, please join us. You are also invited to donor your used clothes. For further information, please contact Teuku as the chief program cocoordinator at his office or to the following numbers: 021- 7996070 081318777056 17. What is the activity for? A. Collecting used clothes B. Helping their raising activity C. Joining fund raising activity D. Helping victims of earthquakes E. Inviting neighbor to donor used clothes Text 3 is for number 18 The University of Australia The University of Australia has an international reputation for educational professionals and applied research. It is Australia’s largest university, with six campuses, including a specialized technology campus. The university places particular importance on the quality of its teaching and learning programs, and on its working links with industry, business and government. 18. Which information is NOT TRUE about the University of Australia? Latihan Soal UN dan Ujian SNMPTN /PTS 2012/2013 3 A. B. C. D. E. It has an international educational reputation It also has a specialized technology campus It has six technology campuses It is Australia’s largest university It has good relation with industry Text 4 is for number 19 and 20 Quake Rocks Southern Philippines Philippines: A 5,3-magnitude earthquake struck the southern Philippines on Thursday, the U.S. Geological Survey said, but there were no reports of casualties or damage. The undersea quake struck at 11:20 a.m. (03200 GMT) around 96 kilometers south east of the southern city of General Santos on the island of Mindanao, the U.S. agency said. The quake was felt in various cities in Mindanao but was not large enough to cause any major damage or panic, said the Philippine Institute of Volcanology and Seismology (Phivolcs). The archipelago nation, made up of more than 7,000 islands, sits on the Pacific “Ring of fire” where continental plates collide, causing frequent seismic and volcanic activity. (Adapted from the Jakarta Post, December 2008) 19. How do we know that the quake was not considered as a big one? Because .... A. It was an undersea quake B. There was no victims or damage C. The quake was less than 5,3 magnitute D. The distance was deep down the sea E. The quake rocked the center of Mindanao, ...
Jets and Giants fans: This 2013 football season Metro‑North continues to make getting to the New Jersey Meadowlands Sports Complex easy. How? Just “Take the Service Overview Travel Plans Train to the Game®!” Direct Service From Major New Haven Line stations Non-Direct Service From Hudson, Harlem & New Haven Lines KEY PROGRAM HIGHLIGHTS INCLUDE: Service from Stations on the Pascack Valley & Port Jervis Lines to The Meadowlands Sports Complex • one-ticket ride from any MetroA How To Purchase Your “Train To The Game®” Tickets From Any Hudson, Harlem, or New Haven Line Station From Stations on the Pascack Valley & Port Jervis Lines to The Meadowlands Sports Complex Ticket Purchasing Tips Maps New Haven Sunday 1PM Train Schedules 2013 Game Schedule North station to any Giants or Jets football game at the Meadowlands Sports Complex. • irect New Haven Line service for D Sunday, 1 PM games. • on-direct service on Hudson, N Harlem, and New Haven lines. • ascack Valley and Port Jervis Line P service for Rockland, Orange, and Westchester County customers. Service Overview Travel Plans Once again, Metro-North customers can purchase one ticket for travel to the Meadowands Sports Complex l (connecting at the Frank R. Lauten erg Secaucus b Junction Station) for Giants and Jets home games and other events. Here’s what you need to know. For further info mation r about ticket-buying options, refer to the “How to Purchase Your Train to the Game” Tickets section. DIRECT SERVICE FROM MAJOR NEW HAVEN LINE STATIONS • Beginning September 8, 2013, Metro-North will provide direct service from major New Haven Line stations to the Meadowands (connecting at l Secaucus Junction). See our direct service timetables for details. to the Meadowlands Sports Complex for Sunday, 1 PM Games ONLY • In addition, our regularly scheduled service will bring you to Grand Central Terminal, where you’ll be able to make one quick subway transfer to connect to trains from Penn Station-NY to the Meadowands. Schedules are available on our home l page at www.mta.info. • Purchase your round-trip rail ticket to the Meadowlands Sports Complex Station at any Metro-North ticket office, ticket machine, or through WebTicket (www.mta.info). • Direct service will be provided from the following stations: via Secaucus Junction New Haven Line Customers: From major stations, a New Haven Line train will provide direct throughservice (one-seat ride) to NJ TRANSIT’s Secaucus Junction (via Penn Station-NY) for all Sunday, 1 PM kickoff home games. From Secaucus Junction, it’s an easy transfer to the Meadowands Rail Line for an express l ride to the Meadowands Sports Complex Station. l NON-DIRECT SERVICE ON HUDSON, HARLEM & NEW HAVEN LINES – New Haven – Westport – Greenwich – West Haven – South Norwalk – Rye – Bridgeport – Stamford – Larchmont – Fairfield DIRECT NEW HAVEN LINE SERVICE For New Canaan, Danbury and Waterbury Branches, check the schedule for connections, or drive to a New Haven Line station from which direct service is provided. Visit www.mta.info for schedule information. • When you arrive at Secaucus Junction, look for the NJ TRANSIT representative at the fare gates. — Show your train ticket to the representative at the gate. — The express ride from Secaucus Junction to the Sports Complex is approximately 10 minutes. Hudson, Harlem, and New Haven Line Customers: Take Metro-North to Grand Central Terminal, ride the subway to Penn Station-NY, then transfer to a NJ TRANSIT train to the Meadowlands Sports Complex Station (connecting at Secaucus Junction). Free weekend parking is available at many New Haven Line stations. Visit www.mta.info for parking information at your departure station. PASCACK VALLEY & PORT JERVIS LINES Rockland, Orange, and Westchester County Customers: You can get to the Meadowlands Sports Complex Station from Spring Valley, Nanuet, and Pearl River stations on the Pascack Valley Line as well as from Port Jervis Line stations connecting at Secaucus Junction. Check www.mta.info for the most current schedule details. PLEASE NOTE: The Meadowlands Sports Complex Stadium does not allow coolers or any over-sized containers on their property.
Purchase your tickets before boarding train when a ticket agent and/or ticket vending machine is available. A $5 surcharge is applied if TVM or ticket office were open at the time of boarding. NON-DISCRIMINATION POLICY: NJ TRANSIT is committed to ensuring that no person is excluded from, or denied the benefits of, our services on the basis of race, color or national origin as protected by Title VI of the Civil Rights Act of 1964, as amended. No person or group of persons shall be discriminated against with regard to the routing, scheduling or quality of transportation service on the basis of race, color or national origin. Frequency of service, age and quality of vehicles assigned to routes, quality of stations serving different routes, and location of routes may not be determined on the basis of race, color or national origin. Any person who believes that they have, individually, or as a member of any specific class of persons, been subjected to discrimination on the basis of race, color or national origin may file a complaint in writing to NJ TRANSIT Customer Service - Title VI Division, One Penn Plaza East, Newark, NJ 07105. A complaint must be filed within 180 days of the alleged discrimination. MTA Metro-North. Port Jervis Line. Ramsey. Route 17. W ashington St. Davenport Ave. Glen Rock. Boro Hall. With MidTOWN DIRECT service to New York.
Jan 24, 2014 ... To determine if the Metro-North Railroad (Metro-North) used American ... Metro- North, a subsidiary of the Metropolitan Transportation Authority ... To determine if the Metro-North Railroad (Metro-North) used American Recovery and Reinvestment Act (Recovery Act) funds efficiently and for authorized purposes, and whether the funds were properly monitored to prevent fraud, waste and abuse. Our audit covered the period April 30, 2009 to June 30, 2012. Background Metro-North, a subsidiary of the Metropolitan Transportation Authority (MTA), has four projects funded by the Recovery Act, namely, Poughkeepsie Station Building-Doors/Window ($4.6 million), Grand Central Terminal Elevators ($7.7 million), Grand Central Terminal Facilities Rehabilitation ($22.7 million), and Tarrytown Station Improvement ($37.3 million). Key Finding • Our review of Metro-North’s monitoring of employees paid with Recovery Act funds found that Metro-North officials could better monitor their employees to ensure that Recovery Act funds are used for authorized purposes and instances of fraud, waste and abuse are mitigated. MetroNorth officials should improve the timekeeping method used for conductors to better ensure they are actually working the hours they are paid for, require that all overtime is pre-approved and justified prior to being worked, and consider whether it is the most efficient practice and whether government funds are being wasted by paying conductors 2 hours and 40 minutes of overtime every day for indirect tasks such as changing their clothes, washing up, and traveling to and from the project site. Also, an unannounced visit to the Tarrytown Station found one conductor was not at his assigned post when a train made a stop. Key Recommendations • Monitor employees’ time and attendance to ensure that they are only paid for actual hours worked. • Establish agency-wide policies and procedures that govern the use, pre-approval and justification of overtime. • Ensure the most efficient practices are in place and government funds are not wasted by paying overtime for indirect tasks such as employees changing their clothes, washing up and traveling to and from the project site. • Monitor conductors to make sure that they are on site and working at their assigned posts to better ensure the safety of passengers, contract workers and other Metro-North employees when trains stop at a station during ongoing track work. Other Related Audit/Report of Interest Metropolitan Transportation Authority/Long Island Rail Road: Overtime and Other Time and Attendance Matters Found in the Use of Certain Federal Funds (2010-S-2) Division of State Government Accountability
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