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Index of download Football World Cup Body Paint

Learn American English Through English Tutor Online With Ease

English is a widely spoken language of the world. Almost 70 countries in the world use English as an official language. This language finds an important place in school instruction, online communication and business transactions.

Patient Advisory for Stem Cell Therapy and Medical Tourism

August 2013 Patient Advisory for Stem Cell Therapy and Medical Tourism As stakeholders in cellular therapy, the undersigned professional organizations believe it is necessary to share the following important message with patients and families contemplating cell therapy or experimental stem cell procedures. In this document, best practices are outlined to assist patients and family members in their healthcare decisions. Controlled innovation in the context of patient safety is paramount as potential therapeutic products or procedures are researched, tested, advanced and proven. Our organizations have received questions and concerns from patients and this document presents an opportunity to address them. Introduction Advancement of clinical therapies is best done in the setting of rigorous and formal clinical trials and in a structured regulatory framework. This helps assure that safety considerations, professional peer review, and the management of patient rights and obligations are considered and addressed. Some procedures would be considered standard of care, because scientific studies have shown that they are safe and effective. Not all procedures offered to patients in all regions of the world are tested in this manner and not all geographical regions have regulations for cellular therapies or patient protection. Additionally, it is possible that some practitioners may offer stem cell procedures without following the existing regulations. Patients may be seeking treatment for incurable, potentially untreatable diseases and may be susceptible to false promises or may not have access to all of the information needed to make this important decision. As patients and families contemplate voluntarily ...

Cardiac Stem Cell Therapy and the Promise of Heart Regeneration

Perspective Cardiac Stem Cell Therapy and the Promise of Heart Regeneration Jessica C. Garbern1 and Richard T. Lee2,* 1Department of Medicine, Boston Children’s Hospital, Boston, MA 02115, USA Stem Cell Institute, the Brigham Regenerative Medicine Center and the Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA *Correspondence: rlee@partners.org http://dx.doi.org/10.1016/j.stem.2013.05.008 2Harvard Stem cell therapy for cardiac disease is an exciting but highly controversial research area. Strategies such as cell transplantation and reprogramming have demonstrated both intriguing and sobering results. Yet as clinical trials proceed, our incomplete understanding of stem cell behavior is made evident by numerous unresolved matters, such as the mechanisms of cardiomyocyte turnover or the optimal therapeutic strategies to achieve clinical efficacy. In this Perspective, we consider how cardiac stem cell biology has led us into clinical trials, and we suggest that achieving true cardiac regeneration in patients may ultimately require resolution of critical controversies in experimental cardiac regeneration. Introduction The race is on: throughout the world, basic and clinical investigators want to be the first to identify new approaches to regenerate cardiac tissue and to prove the effects of these therapies in patients with heart disease. Despite substantial progress in treating many types of heart disease, the worldwide heart failure burden will remain enormous through this century. The potential of stem cells and the scope of the heart failure problem have fueled a stampede to be the first to achieve human heart regeneration. Cell transplantation approaches are attractive given their...

Stem Cell Therapy: the ethical issues - Nuffield Council on Bioethics

Stem Cell Therapy: the ethical issues a discussion paper Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3EG Telephone: Fax: Email: Website: 020 7681 9619 020 7637 1712 bioethics@nuffieldfoundation.org http://www.nuffieldfoundation.org/bioethics April 2000 © Nuffield Council on Bioethics 2000 All rights reserved. Apart from fair dealing for the purpose of private study, research, criticism or review, no part of the publication may be produced, stored in a retrieval system or transmitted in any form, or by any means, without prior permission of the copyright owners. Nuffield Council on Bioethics Professor Ian Kennedy (Chairman) Professor Martin Bobrow CBE (Deputy Chairman) Professor Tom Baldwin Professor Sir Kenneth Calman KCB FRSE* Reverend Professor Duncan Forrester DD Professor Brian Heap CBE FRS Mrs Rebecca Howard Lady Hornby Professor John Ledingham Mr Derek Osborn CB Professor Catherine Peckham CBE Professor Martin Raff FRS Mr Nick Ross Professor Herbert Sewell Professor Albert Weale FBA * (co-opted member of Council for the period of his Chairmanship of the Working Party on the ethics of healthcare-related research in developing countries) The terms of reference are as follows: 1 to identify and define ethical questions raised by recent advances in biological and medical research in order to respond to, and to anticipate, public concern; 2 to make arrangements for examining and reporting on such questions with a view to promoting public understanding and discussion; this may lead, where needed, to the formulation of new guidelines by the appropriate regulatory or other body; 3 in the light of the outcome of its work, to publish reports; and to make representations, as the Council may judge appropriate. The Nuffield Council on Bioethics is funded jointly by the Medical Research Council, the Nuffield Foundation and the Wellcome Trust Attendees of the Round Table meeting on Stem Cell Therapy: the ethical issues Professor Martin Bobrow CBE, Department of Medical Genetics, Cambridge Institute for Medical Research and Deputy Chairman of Nuffield Council on Bioethics Professor Tom Baldwin, Department of Philosophy, University of York, member of Nuffield Council on Bioethics Lady Hornby, Chairman of The Kingwood Trust, member of Nuffield Council on Bioethics...

Stem cell therapy is helping horses with tendon and ... - Vet-Stem

Ultrasound is used to precisely guide the injection of adipose-derived stem cells into the suspensory ligament. The still-developing technology of stem cell therapy, which uses unspecified cells from the horse’s body, has the potential to help racehorses heal sounder than ever before. A tendon is a bundle of elastic fibers, mostly made of collagen, that attaches muscle to bone and helps move the skeleton. Ligaments are similar but attach bone to bone and provide stability. When a horse bows a tendon, it tears the fibers at a certain point of the tendon (the location results in a name, such as high or low bow), weakening it significantly. When the tendon begins to knit back together, it is significantly hampered by lack of blood flow. Blood provides several healing mechanisms, including adult stem cells, which are able to convert themselves into specific types of cells the body needs to heal itself (in this case, tendon cells). If the tendon does not get enough help, it eventually develops scar tissue, which weakens the tendon because it is nonelastic and haphazardly knitted together. The injury takes a long time to heal – a typical racetrack cure was pinfiring or blistering, followed by six months to a year of turnout. If a horse was brought back to the track and the tendon had mostly healed with scar tissue, the weakened tendon could give way and the injury recur.

Stem Cell Treatments For Cerebral Palsy Factsheet For - UCLA ...

STEM CELLS AND CEREBRAL PALSY Cerebral palsy (CP) is an umbrella term which includes several forms and levels of nonprogressive brain-related injury, which cause limitations in muscle control, movement and mobility (known as neuromotor impairment) and other symptoms that lead to physical disability. CP is caused by many factors, and can include infection before birth, premature birth and lack of oxygen around the time of birth. It is thought that the major common feature in CP is a lack of blood and oxygen to the brain during fetal development and/or delivery, known as a hypoxic-ischemic insult. The cells most vulnerable to this hypoxic-ischemic insult are oligodendrocytes, the support cells that wrap nerve cells (or neurons) with a protective white fat called myelin, hence the term white matter of the brain. Because of this myelin, neurons can send electrical signals efficiently throughout the body. Once oligodendrocytes die, the neurons are no longer protected and they eventually die. If myelin could be replaced before neurons die, neurons could be spared and motor impairments could be lessened. For this reason, scientists are investigating whether lost oligodendrocytes can be replaced with stem cells. Stem cells are unspecialized cells which can become specialized cells such as brain cells, heart cells or muscle cells. The process of developing into a specialized cell is known as differentiation. Stem cells can also multiply over and over again, a process known as proliferation. During the process of proliferation the stem cell either remains unspecialized or, under the right condition, can become a specialized cell such as a brain cell. Replacing neurons themselves would be like trying to rewire a giant switchboard with tens of thousands of ports but no labels, where improper connections could lead to pain. It is for this reason that the aim of many cell transplantation strategies now being tested is to replace lost oligodendrocytes rather than to make and successfully connect new neurons. Recent decades have seen advances in our knowledge of how to study and use stem cells. It is expected we will develop ways to transplant stem cells into damaged tissues to treat and cure injury and diseases like CP. From Mice to Humans...

Patient Handbook on Stem Cell Therapies - A Closer Look at Stem ...

W e have all heard about the extraordinary promise that stem cell research holds for the treatment of a wide range of diseases and conditions. However, there is a lot of work still needed to take this research and turn it into safe and effective treatments. The International Society for Stem Cell Research (ISSCR) is very concerned that stem cell therapies are being sold around the world before they have been proven safe and effective. Stem cell therapies are nearly all new and experimental. In these early stages, they may not work, and there may be downsides. Make sure you understand what to look out for before considering a stem cell therapy. Remember, most medical discoveries are based on years of research performed at universities and companies. There is a long process that shows first in laboratory studies and then in clinical research that something is safe and will work. Like a new drug, stem cell therapies must be assessed and meet certain standards before receiving approval from national regulatory bodies to be used to treat people. What does this really mean for you as a patient, doctor, friend or family member? Below we hope to answer some of your questions on stem cells and stem cell therapies and give you the resources you and your doctor need to make the best decisions possible for treatment. The ISSCR is a non-profit professional stem cell research organization with a commitment to ensure the promise of stem cell research is delivered to patients in a safe, effective and fair manner.

Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem ...

Grafix® Demonstrates Overwhelming Efficacy in Landmark Stem Cell Study for the Treatment of Diabetic Foot Ulcers Grafix closes three times as many wounds as standard of care - the largest relative improvement ever reported in a multi-center, randomized, controlled clinical trial for DFU COLUMBIA, Md. - August 13,2013 - Osiris Therapeutics, Inc. (NASDAQ: OSIR), reported today that its multicenter, randomized, controlled clinical trial comparing the safety and effectiveness of Grafix® to standard of care in patients with chronic diabetic foot ulcers had met the pre-specified stopping rules for overwhelming efficacy as determined by the data monitoring committee during a planned interim analysis. For the primary endpoint, 62% of patients receiving Grafix had complete wound closure compared to only 21% (p<0.0001) of patients who received conventional treatment for their wounds - a relative improvement of 191% and the largest ever reported from such a study. A total of 131 patients were enrolled with the interim analysis being conducted on the first 97 to complete the trial. The trial also reached statistical significance in favor of Grafix on all top-line secondary endpoints, demonstrating faster wound closure and a reduction in the number of treatments needed to achieve wound closure. In the crossover phase of the trial, patients whose wounds failed to close after 12 weeks of standard of care had an 80% closure rate when switched to Grafix. Importantly, patients randomized to receive standard of care were 74% more likely to experience an adverse event than those receiving Grafix (p=0.008). As a result, the blinded phase of the trial is being discontinued immediately and all patients randomized to the control arm will be offered treatment with Grafix. “Today, Osiris has established a new standard in diabetic wound care and has demonstrated to the world the tremendous impact stem cell products can have in medicine,” said C. Randal Mills, Ph.D., Chief Executive Officer. “Diabetic foot ulcers afflict 25% of all diabetics and are responsible for more hospitalizations than any other diabetic complication. With 25 million diabetics in the United States, the cost to our health care system is enormous. Through this rigorous study we have shown that Grafix can heal more patients, in less time, and with fewer complications.”

MacBook Air User's Guide (Manual) - Support - Apple

Congratulations, you and your MacBook Air were made for each other. Built-in iSight camera Video chat with up to three friends anywhere in the world at the same time. www.apple.com/macbookair Mac Help isight Finder Browse the contents of your computer using Cover Flow. Time Machine Automatically back up your files to an extra hard drive. www.apple.com/macosx www.apple.com/macosx Mac Help Mac Help finder time machine iMovie Collect all your video in one library. Create and share movies in minutes. iPhoto Organize all your photos with Events. Publish to a Web Gallery with a click. www.apple.com/ilife/imovie www.apple.com/ilife/iphoto iMovie Help iPhoto Help movie GarageBand Create music by adding musicians to a virtual stage. Enhance your song to sound like a pro. www.apple.com/ilife/garageband GarageBand Help record photo iWeb Create beautiful websites with photos, movies, blogs, podcasts, and dynamic web widgets. www.apple.com/ilife/iweb iWeb Help website Contents Chapter 1: Ready, Set Up, Go 8 9 10 15 16 19 22 Welcome What’s in the Box Setting Up Your MacBook Air Setting Up DVD or CD Sharing Migrating Information to Your MacBook Air Getting Additional Information onto Your MacBook Air Putting Your MacBook Air to Sleep or Shutting It Down Chapter 2: Life with Your MacBook Air 26 28 30 32 34 35 Basic Features of Your MacBook Air Keyboard Features of Your MacBook Air Ports on Your MacBook Air Using the Trackpad and Keyboard Running Your MacBook Air on Battery Power Getting Answers Chapter 3: Problem, Meet Solution 40 Problems That Prevent You from Using Your MacBook Air 44 Using Apple Hardware Test Contents

METRO NORTh iNITIATIVE - Mass.Gov
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Initiative Live, Work and Play in these ten communities within Greater Boston: Charlestown, Chelsea, East Boston, Everett, Malden, Medford, Melrose, Revere, Somerville, Winthrop For Massachusetts to double its innovation economy in the next ten years, it must expand where businesses settle and people live, work and play. The Executive Office of Housing and Economic Development and the Metro North communities are working together because Metro North has the potential for smart and dynamic growth. It is within six miles of our financial and innovation clusters. It is connected by the Orange and Blue lines—and soon by the Green and Silver lines. It has great walkable neighborhoods, squares and corners. It has slowly been transforming its economic future for years—revitalizing old industrial sites, welcoming new businesses and immigrants from around the world, and building market rate and mixed-income housing. In November 2013, Chelsea, Malden, Melrose and Revere received MassWorks infrastructure grants. See: http://www.mass.gov/hed/economic/eohed/pro/infrastructure/massworks/. In October, MassDOT announced an $83 million silver line extension connecting South Station and the Seaport District with East Boston and Chelsea, with service expected to begin in late 2015, and the Executive Office of Energy and Environmental Affairs announced a $3 million multi-use path providing pedestrian, bicycle, and greenway connections, as well as access to this new transit. The next step, starting November 2013, is a planning process that will involve the communities, the Metropolitan Area Planning Council (MAPC) and the Commonwealth. The process will identify “priority development” and “priority preservation” areas on a local, regional, and state level. In addition, MAPC will analyze opportunities to invest in infrastructure, and to change zoning and permitting, to advance development and preservation. Meanwhile, the Executive Office of Housing and Economic Development is working to promote new and existing businesses in Metro North that involve innovation, the creative economy (including advertising, architecture, arts or other intellectual property products), and food (restaurants and food suppliers). On October 28, 2013, we held a Blue and Orange Innovation Event at East Boston’s Small Business Incubator space. Below are a few examples of what we learned during Secretary Bialecki’s in-depth Metro North tour this spring and summer:...

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